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mTOR Kinase Inhibitor AZD8055

An inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine… 
National Institutes of Health

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2013
2013
Abstract 909: Hsp90 inhibitor AUY922 abrogates mTOR inhibitor AZD8055-induced up-regulation of HER2/HER3 and potentiates antiproliferative activity in human breast cancer cells.
Mammalian target of rapamycin (mTOR) has been validated as a promising target for cancer therapy. Several mTOR kinase inhibitors… 
2012
2012
Abstract 4835: Genetic determinants of mTOR inhibitor response in breast and endometrial cancer
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Background: Breast and endometrial cancers… 
2011
2011
Abstract 4495: Treatment effects of the novel mTOR kinase inhibitor AZD8055 in prostate cancer cell models
The mTOR pathway is frequently hyperactivated in prostate cancer due to PTEN loss of function, hence rendering prostate cancer… 
2010
2010
157 The mTOR kinase inhibitor AZD8055 induces cell death in Her2+ tumours partially or intrinsically resistant to ErbB2 inhibitors
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