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Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential.
Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins
TLDR
The differential roles of Chk1 and Chk2 in regulating HR repair and G2-M phase arrest are systematically dissected in a favorable model pursuing CPT-driven DNA damage responses, providing critical evidence to further explore checkpoint modulation.
Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.
TLDR
This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years.
The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma
TLDR
High expression of pIgR was statistically significantly associated with early recurrence in early-stage HCC and in hepatitis B surface antigen–positive HCC patients and was sufficient to induce EMT through activation of Smad signaling.
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression
TLDR
GV-971, a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China, suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation, harnesses neuroinflammation and reverses the cognition impairment.
PE, a new sulfated saponin from sea cucumber, Exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo
TLDR
In vitro and in vivo anti-angiogenic activity associated with inhibition of VEGFR2 signaling, and an anti-tumorActivity associated with decreased proliferation of tumor cells and increased apoptosis of both endothelial cells and tumor cells are indicated.
AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo
TLDR
Tumor growth inhibition induced by a single dose of AST1306 in the SK-OV-3 xenograft model was accompanied by a rapid and sustained inhibition of both EGFR and ErbB2, consistent with an irreversible inhibition mechanism.
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