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Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential.
Molecularly targeted cancer therapy: some lessons from the past decade.
Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins
- Min Huang, Z. Miao, Hong Zhu, Yu-Jun Cai, W. Lu, Jian Ding
- Biology, ChemistryMolecular Cancer Therapeutics
- 1 June 2008
The differential roles of Chk1 and Chk2 in regulating HR repair and G2-M phase arrest are systematically dissected in a favorable model pursuing CPT-driven DNA damage responses, providing critical evidence to further explore checkpoint modulation.
Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.
- Zhao‐Li Zhou, Ya-xi Yang, Jian Ding, Yuan‐chao Li, Z. Miao
- ChemistryNatural product reports
- 1 April 2012
This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years.
Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms
The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma
- Jing Ai, Qingjuan Tang, M. Geng
- Medicine, BiologyJournal of the National Cancer Institute
- 24 October 2011
High expression of pIgR was statistically significantly associated with early recurrence in early-stage HCC and in hepatitis B surface antigen–positive HCC patients and was sufficient to induce EMT through activation of Smad signaling.
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression
GV-971, a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China, suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation, harnesses neuroinflammation and reverses the cognition impairment.
PE, a new sulfated saponin from sea cucumber, Exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo
In vitro and in vivo anti-angiogenic activity associated with inhibition of VEGFR2 signaling, and an anti-tumorActivity associated with decreased proliferation of tumor cells and increased apoptosis of both endothelial cells and tumor cells are indicated.
Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer.
AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo
Tumor growth inhibition induced by a single dose of AST1306 in the SK-OV-3 xenograft model was accompanied by a rapid and sustained inhibition of both EGFR and ErbB2, consistent with an irreversible inhibition mechanism.