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Breast cancer metastasis: markers and models
New molecular technologies, such as DNA microarrays, support the idea that metastatic capacity might be an inherent feature of breast tumours and have important implications for prognosis predicition and the understanding of metastasis. Expand
Concordance among gene-expression-based predictors for breast cancer.
Four of the five gene sets used for prognostication in patients with breast cancer showed significant agreement in the outcome predictions for individual patients and are probably tracking a common set of biologic phenotypes. Expand
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
The construction of a set of retroviral vectors encoding 23,742 distinct shRNAs, which target 7,914 different human genes for suppression, is reported, which confers resistance to both p53-dependent and p19ARF-dependent proliferation arrest, and abolishes a DNA-damage-induced G1 cell-cycle arrest. Expand
Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
The purpose of this article was to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists. Expand
Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas
- B. Kreike, Marieke van Kouwenhove, +4 authors M. J. van de Vijver
- Biology, Medicine
- Breast Cancer Research
- 2 October 2007
Triple-negative tumors are synonymous with basal-like tumors, and can be identified by immunohistochemistry, based on gene-expression profiling, which revealed five distinct subgroups of triple-negative breast cancers. Expand
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
- L. De Mattos-Arruda, R. Mayor, +27 authors J. Seoane
- Biology, Medicine
- Nature communications
- 10 November 2015
It is shown that ctDNA derived from central nervous system tumours is more abundantly present in the cerebrospinal fluid (CSF) than in plasma, allowing the identification of actionable brain tumour somatic mutations and facilitating and complement the diagnosis of leptomeningeal carcinomatosis. Expand
Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer
- I. Garcia-Murillas, G. Schiavon, +12 authors N. Turner
- Science Translational Medicine
- 26 August 2015
In a prospective cohort of 55 early breast cancer patients receiving neoadjuvant chemotherapy, detection of ctDNA in plasma after completion of apparently curative treatment—either at a single postsurgical time point or with serial follow-up plasma samples—predicted metastatic relapse with high accuracy and increased sensitivity. Expand
Classification of endometrial carcinoma: more than two types.
An overview of traditional and newer genomic classifications of endometrial cancer is provided and how a classification system that incorporates genomic and histopathological features to define biologically and clinically relevant subsets of the disease would be useful is discussed. Expand
Histological and molecular types of breast cancer: is there a unifying taxonomy?
The historical aspects of breast cancer taxonomy are reviewed, the possible origins of the diversity of breast Cancer are discussed, and an approach for the identification of novel therapeutic targets on the basis of histological special types of breast cancers is proposed. Expand
The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade
A fair and balanced assessment of what microarray‐based gene expression analysis has taught us in the last decade and its contribution to breast cancer classification, prognostication and prediction is provided. Expand