AZD8055

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2018
0102020102018

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2013
2013
The optimization of a potent and highly selective series of dual mTORC1 and mTORC2 inhibitors is described. An initial focus on… (More)
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Highly Cited
2012
Highly Cited
2012
The serine/threonine kinase mammalian target of rapamycin (mTOR) is crucial for cell growth and proliferation, and is… (More)
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2012
2012
Background:This study assessed the safety, tolerability, pharmacokinetics and pharmacodynamics of the first-in-class dual… (More)
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2012
2012
The mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase/AKT signaling pathways interact at multiple nodes in… (More)
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2012
2012
BACKGROUND AZD8055 is a small molecule ATP-competitive inhibitor of the serine/threonine kinase mTOR that regulates cap-dependent… (More)
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2011
2011
mTOR is a central mediator of cancer cell growth, but it also directs immune cell differentiation and function. On this basis, we… (More)
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2011
2011
3096 Background: AZD8055 is a dual mTORC1/mTORC2 inhibitor with properties that prevent the feedback activation of AKT seen with… (More)
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2011
2011
AZD8055 is an ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) that forms two multiprotein complexes, mTORC1 and… (More)
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Highly Cited
2010
Highly Cited
2010
The mammalian target of rapamycin (mTOR) kinase forms two multiprotein complexes, mTORC1 and mTORC2, which regulate cell growth… (More)
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2010
2010
mTOR is a major biological switch, coordinating an adequate response to changes in energy uptake (amino acids, glucose), growth… (More)
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