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losoxantrone

Known as: 7-hydroxy-2(2-((2-hydroxyethyl) amino) ethyl)5-(2-((2-hydroxyethyl)amino)ethyl)amino anthra(1,9-cd)pyrazole-6(2H)-one 
An anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits… Expand
National Institutes of Health

Papers overview

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2006
2006
A series of 13 anthrapyrazole compounds that are analogues of piroxantrone and losoxantrone were synthesized, and their cell… Expand
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2002
2002
The oxidative biotransformation of the anticancer drug 7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino… Expand
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2001
2001
Losoxantrone is an anthrapyrazole derivative in Phase III development in the U.S. for solid tumors, notably breast cancer. To… Expand
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2000
2000
Our purpose in this study was to determine the efficacy and toxicity of losoxantrone (DuP-941), an anthrapyrazole, in patients… Expand
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Review
1999
Review
1999
Numerous clinical trials have demonstrated that the combination of paclitaxel and doxorubicin is extremely active in metastatic… Expand
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1999
1999
A Phase I and pharmacological study was performed to evaluate the feasibility, maximum tolerated dose (MTD), dose-limiting… Expand
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1998
1998
Comparisons were made of the toxic effects produced in the heart, kidney and small intestine of spontaneously hypertensive rats… Expand
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1996
1996
The validation of a procedure designed to clean glass and stainless steel surfaces after exposure to the experimental anticancer… Expand
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1994
1994
BACKGROUND The cumulative cardiotoxicity of anthracyclines is thought to result from the generation of free radicals. New DNA… Expand
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Review
1994
Review
1994
The drug discovery programs of the National Cancer Institute and the pharmaceutical industry recently have provided oncologists… Expand
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