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losoxantrone

Known as: 7-hydroxy-2(2-((2-hydroxyethyl) amino) ethyl)5-(2-((2-hydroxyethyl)amino)ethyl)amino anthra(1,9-cd)pyrazole-6(2H)-one 
An anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits… 
National Institutes of Health

Papers overview

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2002
2002
The oxidative biotransformation of the anticancer drug 7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino… 
Review
2001
Review
2001
2001
2001
The physicochemical and DNA-binding properties of anticancer 9-aza-anthrapyrazoles (9-aza-APs) were investigated and compared… 
2000
2000
Our purpose in this study was to determine the efficacy and toxicity of losoxantrone (DuP-941), an anthrapyrazole, in patients… 
Review
1999
Review
1999
PURPOSE New agents for the palliative treatment of metastatic breast cancer have emerged in the 1990s. This review summarizes the… 
1999
1999
A Phase I and pharmacological study was performed to evaluate the feasibility, maximum tolerated dose (MTD), dose-limiting… 
1996
1996
The validation of a procedure designed to clean glass and stainless steel surfaces after exposure to the experimental anticancer… 
Highly Cited
1994
Highly Cited
1994
BACKGROUND The cumulative cardiotoxicity of anthracyclines is thought to result from the generation of free radicals. New DNA… 
Review
1994
Review
1994
The drug discovery programs of the National Cancer Institute and the pharmaceutical industry recently have provided oncologists…