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losoxantrone

Known as: 7-hydroxy-2(2-((2-hydroxyethyl) amino) ethyl)5-(2-((2-hydroxyethyl)amino)ethyl)amino anthra(1,9-cd)pyrazole-6(2H)-one 
An anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
A series of 13 anthrapyrazole compounds that are analogues of piroxantrone and losoxantrone were synthesized, and their cell… Expand
2002
2002
The oxidative biotransformation of the anticancer drug 7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino… Expand
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2001
2001
The physicochemical and DNA-binding properties of anticancer 9-aza-anthrapyrazoles (9-aza-APs) were investigated and compared… Expand
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2000
2000
Our purpose in this study was to determine the efficacy and toxicity of losoxantrone (DuP-941), an anthrapyrazole, in patients… Expand
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1999
1999
A Phase I and pharmacological study was performed to evaluate the feasibility, maximum tolerated dose (MTD), dose-limiting… Expand
Review
1999
Review
1999
  • P. Kaufman
  • Seminars in oncology
  • 1999
  • Corpus ID: 40309823
Numerous clinical trials have demonstrated that the combination of paclitaxel and doxorubicin is extremely active in metastatic… Expand
1998
1998
Comparisons were made of the toxic effects produced in the heart, kidney and small intestine of spontaneously hypertensive rats… Expand
1996
1996
The validation of a procedure designed to clean glass and stainless steel surfaces after exposure to the experimental anticancer… Expand
Highly Cited
1994
Highly Cited
1994
BACKGROUND The cumulative cardiotoxicity of anthracyclines is thought to result from the generation of free radicals. New DNA… Expand
Review
1994
Review
1994
The drug discovery programs of the National Cancer Institute and the pharmaceutical industry recently have provided oncologists… Expand