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losoxantrone
Known as:
7-hydroxy-2(2-((2-hydroxyethyl) amino) ethyl)5-(2-((2-hydroxyethyl)amino)ethyl)amino anthra(1,9-cd)pyrazole-6(2H)-one
An anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits…
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National Institutes of Health
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Related topics
Related topics
10 relations
Broader (3)
Anthraquinones
Antineoplastic Agents
Pyrazolones
Narrower (3)
Biantrazole
CI 941
DuP 941
Losoxantrone Hydrochloride
NSC 357885
anthrapyrazolone
cyclophosphamide/losoxantrone
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
The oxidative biotransformation of losoxantrone (CI-941).
U. Renner
,
G. Piperopoulos
,
R. Gebhardt
,
G. Ehninger
,
K. Zeller
Drug Metabolism And Disposition
2002
Corpus ID: 7733104
The oxidative biotransformation of the anticancer drug 7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino…
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2001
2001
Elimination pathways of [14C]losoxantrone in four cancer patients.
A. Joshi
,
H. Pieniaszek
,
+6 authors
M. Ratain
Drug Metabolism And Disposition
2001
Corpus ID: 26020853
Losoxantrone is an anthrapyrazole derivative in Phase III development in the U.S. for solid tumors, notably breast cancer. To…
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2001
2001
DNA-interactive anticancer aza-anthrapyrazoles: biophysical and biochemical studies relevant to the mechanism of action.
C. Sissi
,
S. Moro
,
+6 authors
M. Palumbo
Molecular Pharmacology
2001
Corpus ID: 9197256
The physicochemical and DNA-binding properties of anticancer 9-aza-anthrapyrazoles (9-aza-APs) were investigated and compared…
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2001
2001
A Novel 9-Aza-Anthrapyrazole Effective against Human Prostatic Carcinoma Xenografts
R. Supino
,
D. Polizzi
,
+16 authors
F. Zunino
Oncology
2001
Corpus ID: 1499225
Objectives: Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the…
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2000
2000
A multicenter phase II trial of losoxantrone (DuP-941) in hormone-refractory metastatic prostate cancer.
S. Huan
,
R. Natale
,
+5 authors
M. Finizio
Clinical Cancer Research
2000
Corpus ID: 9672428
Our purpose in this study was to determine the efficacy and toxicity of losoxantrone (DuP-941), an anthrapyrazole, in patients…
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1999
1999
Stimulation of topoisomerase II-mediated DNA cleavage by an indazole analogue of lucanthone.
L. Dassonneville
,
C. Bailly
Biochemical Pharmacology
1999
Corpus ID: 23347163
1999
1999
A phase I and pharmacokinetic study of losoxantrone and paclitaxel in patients with advanced solid tumors.
S. Diab
,
S. Baker
,
+12 authors
E. Rowinsky
Clinical Cancer Research
1999
Corpus ID: 27749346
A Phase I and pharmacological study was performed to evaluate the feasibility, maximum tolerated dose (MTD), dose-limiting…
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Review
1999
Review
1999
Paclitaxel and anthracycline combination chemotherapy for metastatic breast cancer.
P. Kaufman
Seminars in Oncology
1999
Corpus ID: 40309823
Numerous clinical trials have demonstrated that the combination of paclitaxel and doxorubicin is extremely active in metastatic…
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1996
1996
Validation of cleaning procedures for highly potent drugs. I. Losoxantrone.
J. A. Shea
,
W. Shamrock
,
+4 authors
J. Segretario
Pharmaceutical development and technology (Print)
1996
Corpus ID: 36364424
The validation of a procedure designed to clean glass and stainless steel surfaces after exposure to the experimental anticancer…
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Review
1994
Review
1994
New chemotherapeutic agents for breast cancer
J. Abrams
,
T. Moore
,
M. Friedman
Cancer
1994
Corpus ID: 25621940
The drug discovery programs of the National Cancer Institute and the pharmaceutical industry recently have provided oncologists…
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