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CI 941

Known as: CI-941, CI941 
 
National Institutes of Health

Papers overview

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2002
2002
The oxidative biotransformation of the anticancer drug 7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino… Expand
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1996
1996
The reversing effect of p-glycoprotein (Pgp) inhibitors on the multidrug resistance (MDR) phenotype is well established in a… Expand
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1992
1992
SummaryThe MCF-7 cell S9 fraction and whole MCF-7 cells can mediate one-electron-redox cycling of doxorubicin, giving rise to… Expand
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1992
1992
The development of new drugs in early clinical trials is currently based upon the results of preclinical antitumour and toxicity… Expand
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1992
1992
The pharmacokinetics of the anthrapyrazole CI-941 has been investigated in conjunction with the Phase I evaluation of the drug… Expand
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1991
1991
Thirty-one patients with advanced breast cancer were treated with CI941, an anthrapyrazole structurally related to mitoxantrone… Expand
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Review
1991
Review
1991
The anthrapyrazoles are a new class of intercalating agents which were synthesized in order to reduce the potential for free… Expand
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1989
1989
SummaryCI-941 is a new synthetic DNA-binding agent selected for phase I clinical evaluation. The drug has broad-spectrum… Expand
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1989
1989
This assay has facilitated the accurate determination of the pharmacokinetics of the drug in patients treated at the phase I… Expand
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1987
1987
The anthrapyrazole CI941 is one of a new series of DNA complexing drugs which displays high level broad spectrum antitumour… Expand
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