Skip to search formSkip to main contentSkip to account menu

linaclotide

Known as: Cys cys glu tyr cys cys asn pro ala cys thr gly cys tyr (disulfide bridge: 1-6; 2-10; 5-13), L-Cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclic (1->6),(2->10),(5->13)-tris(disulfide), L-Tyrosine, L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L- asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1->6), (2->10), (5->13)-tris(disulfide) 
A synthetic, fourteen amino acid peptide and agonist of intestinal guanylate cyclase type C (GC-C), which is structurally related to the guanylin… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

Linaclotide AcetateMD-1100

Broader (1)

Peptides
linaclotide 0.145 MG Oral Capsulelinaclotide 0.29 MG Oral Capsule [Linzess]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline
Abstract Objective To formulate timely evidence-based guidelines for the management of opioid-induced bowel dysfunction. Setting… 
Highly Cited
2014
Highly Cited
2014
Carbon dots as fluorescent probes for "off-on" detection of Cu2+ and L-cysteine in aqueous solution.
Highly Cited
2009
Highly Cited
2009
Development of aliphatic biodegradable photoluminescent polymers
None of the current biodegradable polymers can function as both implant materials and fluorescent imaging probes. The objective… 
Highly Cited
2008
Highly Cited
2008
The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair
Deciphering the mechanisms regulating the generation of new neurons and new oligodendrocytes, the myelinating cells of the… 
Highly Cited
2005
Highly Cited
2005
Determination of the production rate and non‐renal clearance of cystatin C and estimation of the glomerular filtration rate from the serum concentration of cystatin C in humans
Cystatin C has been proposed as an endogenous marker for measuring glomerular filtration rate (GFR) and is regarded as being… 
Review
2004
Review
2004
Distribution of receptor targets in the lung.
  • P. Barnes
  • Proceedings of the American Thoracic Society
  • 2004
  • Corpus ID: 24490094
Most of the drugs that are currently used to treat airway diseases interact with receptors expressed by cells in the airways… 
Highly Cited
1999
Highly Cited
1999
An immunomodulatory polysaccharide‐rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity
The fruit juice of Morinda citrifolia (noni) contains a polysaccharide‐rich substance (noni‐ppt) with antitumour activity in the… 
Review
1996
Review
1996
A family of UDP-GalNAc: polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation.
Enzymatic glycosylation of proteins involves the addition of a monosaccharide or, in the case of N-linked glycosylation of… 
Highly Cited
1992
Highly Cited
1992
Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro.
Highly Cited
1984
Highly Cited
1984
Disulfide bond formation in proteins.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)