linaclotide

Known as: Cys cys glu tyr cys cys asn pro ala cys thr gly cys tyr (disulfide bridge: 1-6; 2-10; 5-13), L-Cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclic (1->6),(2->10),(5->13)-tris(disulfide), L-Tyrosine, L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L- asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1->6), (2->10), (5->13)-tris(disulfide) 
A synthetic, fourteen amino acid peptide and agonist of intestinal guanylate cyclase type C (GC-C), which is structurally related to the guanylin… (More)

Topic mentions per year

Topic mentions per year

1978-2018
0204019782018

Papers overview

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Highly Cited
2012
Highly Cited
2012
OBJECTIVES:Linaclotide is a minimally absorbed peptide guanylate cyclase-C agonist. The objective of this trial was to determine… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. In two trials, we aimed to… (More)
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2010
2010
BACKGROUND & AIMS Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase-C receptor that stimulates… (More)
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Highly Cited
2010
Highly Cited
2010
Linaclotide is a first-in-class, orally administered 14-amino acid peptide that is in development for the treatment of irritable… (More)
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2010
2010
BACKGROUND Linaclotide is a novel, orally administered investigational drug currently in clinical development for the treatment… (More)
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2010
2010
BACKGROUND & AIMS Linaclotide, a minimally absorbed, 14-amino acid peptide agonist of guanylate cyclase-C, has shown benefit in a… (More)
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2010
2010
AIMS Linaclotide is an orally administered 14-amino acid peptide being developed for the treatment of constipation-predominant… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND & AIMS Oral linaclotide, a novel agonist of guanylate cylase-C, stimulates intestinal fluid secretion and transit, and… (More)
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2004
2004
BACKGROUND Cysteinyl-leukotrienes (cys-LTs) and 8-isoprostane are biomarkers of airway inflammation and oxidative stress… (More)
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Highly Cited
2002
Highly Cited
2002
The pathogenesis of aspirin-induced asthma (AIA) has not yet been clearly elucidated, although eicosanoid metabolites appear to… (More)
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