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linaclotide

Known as: Cys cys glu tyr cys cys asn pro ala cys thr gly cys tyr (disulfide bridge: 1-6; 2-10; 5-13), L-Cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclic (1->6),(2->10),(5->13)-tris(disulfide), L-Tyrosine, L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L- asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1->6), (2->10), (5->13)-tris(disulfide) 
A synthetic, fourteen amino acid peptide and agonist of intestinal guanylate cyclase type C (GC-C), which is structurally related to the guanylin… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

Linaclotide AcetateMD-1100

Broader (1)

Peptides
linaclotide 0.145 MG Oral Capsulelinaclotide 0.29 MG Oral Capsule [Linzess]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Prostaglandin E2 systemic production in patients with asthma with and without aspirin hypersensitivity
Background: A special regulatory role for prostaglandin E2 has been postulated in aspirin-induced asthma. A study was undertaken… 
Highly Cited
2006
Highly Cited
2006
Urine leukotriene E4 levels are associated with decreased pulmonary function in children with persistent airway obstruction.
Highly Cited
2004
Highly Cited
2004
Cysteine-induced hypoglycemic brain damage: an alternative mechanism to excitotoxicity
Summary.Central neural damage caused by L-cysteine (L-Cys) was first reported more than 30 years ago. Nevertheless, the exact… 
Review
1996
Review
1996
A family of UDP-GalNAc: polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation.
Enzymatic glycosylation of proteins involves the addition of a monosaccharide or, in the case of N-linked glycosylation of… 
Highly Cited
1995
Highly Cited
1995
Using evolutionary changes to achieve species-specific inhibition of enzyme action--studies with triosephosphate isomerase.
Highly Cited
1989
Highly Cited
1989
Geometry of interaction of metal ions with sulfur-containing ligands in protein structures.
An analysis of the geometry of binding of metal ions by cysteine and methionine residues in protein structures has been made by… 
Highly Cited
1986
Highly Cited
1986
Binding of N-linked bovine fetuin glycopeptides to isolated rabbit hepatocytes: Gal/GalNAc hepatic lectin discrimination between Gal beta(1,4)GlcNAc and Gal beta(1,3)GlcNAc in a triantennary…
Glycopeptides were isolated from bovine fetuin after digestion with Pronase, aminopeptidase M, and carboxypeptidase Y. The… 
Highly Cited
1981
Highly Cited
1981
Amino acid sequence of heat-stable enterotoxin produced by Escherichia coli pathogenic for man.
Highly Cited
1979
Highly Cited
1979
Monoamine oxidase from beef liver mitochondria: simplified isolation procedure, properties, and determination of its cysteinyl flavin content.
Highly Cited
1971
Highly Cited
1971
Proposed conformation of oxytocin in solution.
A conformation of the neurohypophyseal hormone oxytocin in solution is proposed. The structure possesses, in addition to the beta… 
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