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Attaching and effacing activities of rabbit and human enteropathogenic Escherichia coli in pig and rabbit intestines.
Three strains of enteropathogenic Escherichia coli (EPEC), originally isolated from humans and previously shown to cause diarrhea in human volunteers by unknown mechanisms, and one rabbit EPEC strainExpand
Mice Lacking the Basolateral Na-K-2Cl Cotransporter Have Impaired Epithelial Chloride Secretion and Are Profoundly Deaf*
In chloride-secretory epithelia, the basolateral Na-K-2Cl cotransporter (NKCC1) is thought to play a major role in transepithelial Cl− and fluid transport. Similarly, in marginal cells of the innerExpand
Suckling mouse model for detection of heat-stable Escherichia coli enterotoxin: characteristics of the model.
  • R. Giannella
  • Biology, Medicine
  • Infection and immunity
  • 1 July 1976
Although the suckling mouse assay is widely used for the detection of heat-stable Escherichia coli enterotoxin (ST), few data have been published concerning the reproducibility, optimal growth, andExpand
Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro
Reassessment of the `gastric bactericidal barrier' to enteric bacteria in man included studies of the bactericidal activity of (1) the normal and achlorhydric stomach in vivo and (2) normal andExpand
Pathogenesis of salmonellosis. Studies of fluid secretion, mucosal invasion, and morphologic reaction in the rabbit ileum.
Strains of Salmonella typhimurium were studied in the ligated rabbit ileal loop model to gain insight into the mechanisms whereby bacteria which invade the gastrointestinal mucosa evoke fluidExpand
Mechanisms of infectious diarrhea
Infectious diarrhea is an important public health problem worldwide. Research has provided new insights into the mechanisms of diarrhea caused by various pathogens that are classified asExpand
Purification and characterization of heat-stable enterotoxin produced by a strain of E. coli pathogenic for man.
Escherichia coli heat-stable enterotoxin derived from a strain pathogenic for man has been purified 13,000-fold to apparent homogeneity. The purification scheme involved growth in a minimal medium.Expand
Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion.
Heat-stable enterotoxin (STa) is an important causative agent of diarrheal disease throughout the world. STa is known to bind specifically to receptors in the intestine, provoking intense intestinalExpand
Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor.
BACKGROUND Guanylin (GN) and uroguanylin (UGN) are intestinally derived peptide hormones that are similar in structure and activity to the diarrhea-causing Escherichia coli heat-stable enterotoxinsExpand
A clinicopathologic study of enterocyte-adherent Escherichia coli: a cause of protracted diarrhea in infants.
Fifteen infants (age 3-28 wk) suffered from severe diarrhea with acute dehydration and poor growth. Persistent watery stools and suboptimal nutrition necessitated central venous alimentation withExpand