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lexitropsin
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (3)
Antineoplastic Agents
Antiviral Agents
Netropsin
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole.
N. Anthony
,
Blair F. Johnston
,
+4 authors
R. Waigh
Journal of the American Chemical Society
2004
Corpus ID: 22896262
Isopropyl-thiazole ((iPr)Th) represents a new addition to the building blocks of nucleic acid minor groove-binding molecules. The…
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2004
2004
DNA binding of a short lexitropsin.
N. Anthony
,
K. Fox
,
+7 authors
R. Waigh
Bioorganic & medicinal chemistry letters
2004
Corpus ID: 24261450
Footprinting, capillary electrophoresis, molecular modelling and NMR studies have been used to examine the binding of a short…
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Review
2001
Review
2001
Recent developments in sequence selective minor groove DNA effectors.
B. Reddy
,
Sandeep Savitaprakash Sharma
,
J. Lown
Current medicinal chemistry
2001
Corpus ID: 45522300
DNA is a well characterized intracellular target but its large size and sequential nature make it an elusive target for selective…
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Highly Cited
1997
Highly Cited
1997
Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G.
M. Kopka
,
D. Goodsell
,
G. W. Han
,
T. K. Chiu
,
J. Lown
,
R. E. Dickerson
Structure
1997
Corpus ID: 39755337
BACKGROUND Polyamide drugs, such as netropsin, distamycin and their lexitropsin derivatives, can be inserted into a narrow B-DNA…
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1995
1995
Structure of a dicationic monoimidazole lexitropsin bound to DNA.
D. Goodsell
,
H. L. Ng
,
M. Kopka
,
J. Lown
,
R. E. Dickerson
Biochemistry
1995
Corpus ID: 38706112
An X-ray crystal structure has been solved of the complex of a dicationic lexitropsin with a B-DNA duplex of sequence…
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Review
1994
Review
1994
DNA recognition by lexitropsins, minor groove binding agents
J. Lown
Journal of molecular recognition : JMR
1994
Corpus ID: 10088740
Consideration is given to alternative approaches to the development of DNA sequences selective binding agents because of their…
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1992
1992
Anti-HIV-I activity of linked lexitropsins.
W. Wang
,
J. Lown
Journal of medicinal chemistry
1992
Corpus ID: 23326175
Five groups of lexitropsin oligopeptides have been synthesized that are structurally related to the natural antiviral agents…
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1990
1990
N-(2-chloroethyl)-N-nitrosoureas covalently bound to nonionic and monocationic lexitropsin dipeptides. Synthesis, DNA affinity binding characteristics, and reactions with 32P-end-labeled DNA.
K. Church
,
R. Wurdeman
,
Y. Zhang
,
F. X. Chen
,
B. Gold
Biochemistry
1990
Corpus ID: 45548845
The synthesis and characterization of a series of compounds that contain an N-alkyl-N-nitrosourea functionality linked to DNA…
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1988
1988
Sequence specific molecular recognition by a monocationic lexitropsin of the decadeoxyribonucleotide d-[CATGGCCATG]2: structural and dynamic aspects deduced from high field 1H-NMR studies.
M. Lee
,
J. Hartley
,
R. Pon
,
K. Krowicki
,
J. Lown
Nucleic acids research
1988
Corpus ID: 19839886
All 1H-NMR resonances of d-[CATGGCCATG]2 and the 1:1 complex of lexitropsin 1 and the DNA were assigned by the NOE difference…
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1988
1988
Structural and dynamic aspects of binding of a prototype lexitropsin to the decadeoxyribonucleotide d(CGCAATTGCG)2 deduced from high-resolution 1H NMR Studies.
M. Lee
,
D. Chang
,
J. Hartley
,
R. Pon
,
K. Krowicki
,
J. Lown
Biochemistry
1988
Corpus ID: 33610007
Structural and dynamic properties of the self-complementary decadeoxyribonucleotide d(CGCAATTGCG)2 and the interaction between a…
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