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lexitropsin

 
National Institutes of Health

Related topics

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4 relations

Broader (3)

Antineoplastic AgentsAntiviral AgentsNetropsin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole.
Isopropyl-thiazole ((iPr)Th) represents a new addition to the building blocks of nucleic acid minor groove-binding molecules. The… Expand
2004
2004
DNA binding of a short lexitropsin.
Footprinting, capillary electrophoresis, molecular modelling and NMR studies have been used to examine the binding of a short… Expand
Review
2001
Review
2001
Recent developments in sequence selective minor groove DNA effectors.
DNA is a well characterized intracellular target but its large size and sequential nature make it an elusive target for selective… Expand
Highly Cited
1997
Highly Cited
1997
Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G.
BACKGROUND Polyamide drugs, such as netropsin, distamycin and their lexitropsin derivatives, can be inserted into a narrow B-DNA… Expand
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1995
1995
Structure of a dicationic monoimidazole lexitropsin bound to DNA.
An X-ray crystal structure has been solved of the complex of a dicationic lexitropsin with a B-DNA duplex of sequence… Expand
Review
1994
Review
1994
DNA recognition by lexitropsins, minor groove binding agents
  • J. Lown
  • Journal of molecular recognition : JMR
  • 1994
    • Corpus ID: 10088740
Consideration is given to alternative approaches to the development of DNA sequences selective binding agents because of their… Expand
1992
1992
Anti-HIV-I activity of linked lexitropsins.
Five groups of lexitropsin oligopeptides have been synthesized that are structurally related to the natural antiviral agents… Expand
1990
1990
N-(2-chloroethyl)-N-nitrosoureas covalently bound to nonionic and monocationic lexitropsin dipeptides. Synthesis, DNA affinity binding characteristics, and reactions with 32P-end-labeled DNA.
The synthesis and characterization of a series of compounds that contain an N-alkyl-N-nitrosourea functionality linked to DNA… Expand
1988
1988
Sequence specific molecular recognition by a monocationic lexitropsin of the decadeoxyribonucleotide d-[CATGGCCATG]2: structural and dynamic aspects deduced from high field 1H-NMR studies.
All 1H-NMR resonances of d-[CATGGCCATG]2 and the 1:1 complex of lexitropsin 1 and the DNA were assigned by the NOE difference… Expand
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1988
1988
Structural and dynamic aspects of binding of a prototype lexitropsin to the decadeoxyribonucleotide d(CGCAATTGCG)2 deduced from high-resolution 1H NMR Studies.
Structural and dynamic properties of the self-complementary decadeoxyribonucleotide d(CGCAATTGCG)2 and the interaction between a… Expand
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