The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
- K. Bonjean, M. De Pauw‐Gillet, L. Angenot
- Biology, ChemistryBiochemistry
- 19 March 1998
Direct evidence is provided that DNA is the primary target of cryptolepine and it is suggested that this alkaloid is a valid candidate for the development of tumor active compounds.
Circular dichroism and magnetic circular dichroism of the chlorophyll and protochlorophyll pigments
- C. Houssier, K. Sauer
- Biology
- 1 February 1970
Triplex and quadruplex DNA structures studied by electrospray mass spectrometry.
- F. Rosu, V. Gabélica, C. Houssier, P. Colson, E. Pauw
- ChemistryRapid Communications in Mass Spectrometry
- 30 September 2002
This is the first report of a triplex DNA structure by electrospray mass spectrometry, and the absence of sodium contamination allowed demonstration of the specific inclusion of n - 1 ammonium cations in the quadruplex structures.
Thermodynamics of cation-induced DNA condensation.
- R. Marquet, C. Houssier
- Physics, ChemistryJournal of Biomolecular Structure and Dynamics
- 1 August 1991
It is shown that the process of DNA condensation becomes spontaneous in the presence of divalent cations in methanol, and in the absence of tri- or tetravalent cationsIn water media.
DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
- J. Goossens, E. Bouey-Bencteux, C. Bailly
- Biology, ChemistryBiochemistry
- 17 March 2001
The results provide the first experimental evidence that DNA is a target of anilinoquinazoline derivatives and suggest that this N-methylated ring system is a valid candidate for the development of DNA-targeted cytotoxic compounds.
Physico-chemical study of the complexes of "33258 Hoechst" with DNA and nucleohistone.
- J. Bontemps, C. Houssier, E. Fredericq
- Chemistry, BiologyNucleic Acids Research
- 1 June 1975
D dye molecules appeared to bind to highly fluorescent sites with their long axis oriented at 45 degree to the helix axis as the binding proceeds, less fluorescent sites are cooperatively occupied and the inclination of these ligand molecules becomes closer to that of the base planes.
Determination of affinity, stoichiometry and sequence selectivity of minor groove binder complexes with double-stranded oligodeoxynucleotides by electrospray ionization mass spectrometry.
- F. Rosu, V. Gabélica, C. Houssier, E. De Pauw
- Chemistry, BiologyNucleic Acids Research
- 15 August 2002
It is shown that ESI-MS can quickly give reliable information on the A/T sequence selectivity of a drug: the signal of a complex is directly related to the affinity of the drug for that particular duplex.
Binding of Hoechst 33258 to the TAR RNA of HIV-1. Recognition of a pyrimidine bulge-dependent structure.
- L. Dassonneville, F. Hamy, P. Colson, C. Houssier, C. Bailly
- Biology, ChemistryNucleic Acids Research
- 1 November 1997
The identification of a binding site for small molecules in TAR offers promising perspectives for developing drugs that would block the access of TAR RNA to proteins and therefore for the design of anti-HIV agents.
The binding mode of drugs to the TAR RNA of HIV-1 studied by electric linear dichroism.
- C. Bailly, P. Colson, C. Houssier, F. Hamy
- Biology, ChemistryNucleic Acids Research
- 1 April 1996
The ELD data show that the mode of binding of the drugs Hoechst 33258, berenil and DAPI to the TAR RNA is similar to their binding mode in GC-rich regions of DNA and likely involves intercalation into the A-form TARRNA helix.
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