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Netropsin

Known as: 1H-Pyrrole-2-carboxamide, 4-((((aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, Sinanomycin, Netropsin [Chemical/Ingredient] 
A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
We have constructed derivatives of Streptomyces coelicolor M145 as hosts for the heterologous expression of secondary metabolite… Expand
Highly Cited
2009
Highly Cited
2009
Copper(II) complexes [Cu(L-arg)(2)](NO(3))(2) (1) and [Cu(L-arg)(B)Cl]Cl (2-5), where B is a heterocyclic base, namely, 2,2… Expand
Highly Cited
2001
Highly Cited
2001
Full details of the development of a simple, nondestructive, and high-throughput method for establishing DNA binding affinity and… Expand
Highly Cited
1990
Highly Cited
1990
We have determined the domains of the mammalian high mobility group (HMG)I chromosomal proteins necessary and sufficient for… Expand
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Highly Cited
1987
Highly Cited
1987
An X-ray crystallographic structure analysis has been carried out on the complex between the antibiotic and DNA fluorochrome… Expand
Review
1986
Review
1986
II. DNA BINDING ANTIBIOTICS 1. Pyrrole-Amidine Antibiotics and Synthetic Analogues (a) Structure and physical properties (b… Expand
Highly Cited
1985
Highly Cited
1985
X-ray analysis of the complex of netropsin with the B-DNA dodecamer of sequence C-G-C-G-A-A-T-T-BrC-G-C-G reveals that the… Expand
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Highly Cited
1985
Highly Cited
1985
The antitumor antibiotic netropsin has been co-crystallized with a double-helical B-DNA dodecanucleotide of sequence: C-G-C-G-A-A… Expand
Highly Cited
1982
Highly Cited
1982
We report a direct technique for determining the binding sites of small molecules on naturally occurring heterogeneous DNA… Expand
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Highly Cited
1974
Highly Cited
1974
Abstract The binding of netropsin to 31 different natural and biosynthetic DNAs, DNA-RNA hybrids, and RNAs was studied in order… Expand