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Netropsin

Known as: 1H-Pyrrole-2-carboxamide, 4-((((aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, Sinanomycin, Netropsin [Chemical/Ingredient] 
A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics… 
National Institutes of Health

Related topics

Related topics

24 relations

Narrower (13)

1-methylimidazole-2-carboxamide netropsinNetropsin HydrochloridePt-bis-netropsinT-1384

Broader (4)

Anti-Bacterial AgentsAntibioticsAntiviral AgentsPeptides
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Energetic diversity of DNA minor-groove recognition by small molecules displayed through some model ligand-DNA systems.
Review
1994
Review
1994
DNA recognition by intercalators and hybrid molecules
Experimental are described which probe the role of the 2‐amino group of guanine as a critical determinant of the recognition of… 
Highly Cited
1992
Highly Cited
1992
Drug binding to higher ordered DNA structures: netropsin complexation with a nucleic acid triple helix.
We have used a combination of spectroscopic and calorimetric techniques to characterize how netropsin, a ligand that binds in the… 
Highly Cited
1983
Highly Cited
1983
Calorimetric and spectroscopic investigation of drug-DNA interactions. I. The binding of netropsin to poly d(AT).
We report the first calorimetric investigation of netropsin binding to poly d(AT). Temperature-dependent uv absorption, circular… 
Highly Cited
1983
Highly Cited
1983
Sequence specificity of actinomycin D and Netropsin binding to pBR322 DNA analyzed by protection from DNase I.
A direct approach to determining the sequence specificities of equilibrium binding drugs by using the DNase protection technique… 
Highly Cited
1982
Highly Cited
1982
Antibiotic-DNA interactions: intermolecular nuclear Overhauser effects in the netropsin-d(C-G-C-G-A-A-T-T-C-G-C-G) complex in solution.
The proton markers located in the minor groove of the d(C-G-C-G-A-A-T-T-C-G-C-G) duplex and its netropsin complex have been… 
Highly Cited
1980
Highly Cited
1980
Interaction of netropsin and distamycin with deoxyribonucleic acid: electric dichroism study.
We report dichroism and equilibrium binding studies of netropsin (Net) and distamycin A3 (Dist) binding to deoxyribonucleic acid… 
Highly Cited
1975
Highly Cited
1975
Transmission of stability (telestability) in deoxyribonucleic acid. Physical and enzymatic studies on the duplex block polymer d(C15A15) - d(T15G15).
Highly Cited
1974
Highly Cited
1974
Netropsin. A specific probe for A-T regions of duplex deoxyribonucleic acid.
Abstract The binding of netropsin to 31 different natural and biosynthetic DNAs, DNA-RNA hybrids, and RNAs was studied in order… 
Highly Cited
1974
Highly Cited
1974
Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.
The binding of the antibiotics netropsin and distamycin A to DNA has been studied by thermal melting, CD and sedimentation… 
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