Netropsin

Known as: 1H-Pyrrole-2-carboxamide, 4-((((aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, Sinanomycin, Netropsin [Chemical/Ingredient] 
A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
0102019532017

Papers overview

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Highly Cited
2011
Highly Cited
2011
We have constructed derivatives of Streptomyces coelicolor M145 as hosts for the heterologous expression of secondary metabolite… (More)
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2011
2011
The genome sequence of Streptomyces ambofaciens, a species known to produce the congocidine and spiramycin antibiotics, has… (More)
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Highly Cited
2001
Highly Cited
2001
Full details of the development of a simple, nondestructive, and high-throughput method for establishing DNA binding affinity and… (More)
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Highly Cited
1999
Highly Cited
1999
The sequence and structural selectivity of 15 different DNA binding agents was explored using a novel, thermodynamically rigorous… (More)
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Highly Cited
1990
Highly Cited
1990
We have determined the domains of the mammalian high mobility group (HMG)I chromosomal proteins necessary and sufficient for… (More)
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1990
1990
Netropsin, distamycin, berenil and the chromosomal protein HMG-I share the ability to bind preferentially to AT-rich regions of… (More)
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Highly Cited
1988
Highly Cited
1988
The electropermeabilization (EPN) of living cells allows the uptake of non-permeant molecules and can reveal their potential… (More)
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Highly Cited
1986
Highly Cited
1986
alpha-Protein is a high mobility group protein originally purified from African green monkey cells based on its affinity for the… (More)
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Highly Cited
1985
Highly Cited
1985
X-ray analysis of the complex of netropsin with the B-DNA dodecamer of sequence C-G-C-G-A-A-T-T-BrC-G-C-G reveals that the… (More)
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1985
1985
The antitumor antibiotic netropsin has been co-crystallized with a double-helical B-DNA dodecanucleotide of sequence: C-G-C-G-A-A… (More)
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