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Netropsin

Known as: 1H-Pyrrole-2-carboxamide, 4-((((aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, Sinanomycin, Netropsin [Chemical/Ingredient] 
A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics… 
National Institutes of Health

Related topics

Related topics

24 relations

Narrower (13)

1-methylimidazole-2-carboxamide netropsinNetropsin HydrochloridePt-bis-netropsinT-1384

Broader (4)

Anti-Bacterial AgentsAntibioticsAntiviral AgentsPeptides
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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1987
1987
Specific activation of transcription initiation by the sequence-specific DNA-binding agents distamycin A and netropsin.
A series of promoters with nine base-pair substitutions in the spacer DNA separating the -10 and -35 regions was used to… 
1987
1987
NMR studies of the interaction of chromomycin A3 with small DNA duplexes I.
1H and 31P NMR spectral analysis of a chromomycin/d(ATGCAT)2 complex provides strong evidence for a nonintercalative mode of drug… 
1986
1986
Binding of non-intercalating antibiotics to B-DNA: a theoretical study taking into account nucleic acid flexibility.
A detailed theoretical study has been made for five antibiotics which all bind selectively to AT sequences in the minor groove of… 
1985
1985
Mode of reversible binding of neocarzinostatin chromophore to DNA: evidence for binding via the minor groove.
Two general approaches have been taken to understand the mechanism of the reversible binding of the nonprotein chromophore of… 
1982
1982
Specific interaction of netropsin, distamycin-3 and analogs with LC duplexes: reversion towards the B form of the 2'-deoxy-.2'-deoxy-2'-fluoro-hybrid duplexes upon specific interaction with netropsin…
Binding of the B-form specific ligands netropsin and distamycin-3, -4 and -5 has been used to monitor the presence and/or the… 
1981
1981
Mutual interaction between adjacent dG . dC actinomycin binding sites and dA . dT netropsin binding sites on the self-complementary d(C-G-C-G-A-A-T-T-C-G-C-G) duplex in solution.
The Watson-Crick imino protons, the backbone phosphodiester resonances, and the antibiotic exchangeable protons have been used as… 
1981
1981
The effect of several nucleic acid binding drugs on the cleavage of d(GGAATTCC) and pBR 322 by the Eco RI restriction endonuclease.
The endonucleolytic action of the EcoRI restriction enzyme on the double-stranded oligonucleotide d(GGAATTCC) and the supercoiled… 
Highly Cited
1980
Highly Cited
1980
Existence of an extended series of antitumor compounds which bind to deoxyribonucleic acid by nonintercalative means.
Viscometric titrations of bacteriophage PM2 closed circular DNA, in addition to spectrophotometric and fluorometric methods, were… 
1979
1979
Netropsin . dG-dG-dA-dA-dT-dT-dC-dC complex. Antibiotic binding at adenine . thymine base pairs in the minor groove of the self-complementary octanucleotide duplex.
The structure of the netropsin . dG-dG-dA-dA-dT-dT-dC-dC complex (one antibiotic molecule/self-complementary octanucleodide… 
1978
1978
Magnetic circular dichroism of netropsin and natural circular dichroism of the netropsin-DNA complex.
We report the first measurement of the magnetic circular dichroism (MCD) of the basic polypeptide antibiotic netropsin (Nt). The…