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leukotriene metabolic process

Known as: leukotriene metabolism 
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Platelets in patients with aspirin-exacerbated respiratory disease.
Aspirin-exacerbated respiratory disease (AERD) is a chronic inflammatory disease characterized clinically by the triad of asthma… Expand
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2008
2008
Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation.
The hedgehog (Hh) pathway is required for many developmental processes, as well as for adult homeostasis. Although all known… Expand
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Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… Expand
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Highly Cited
2007
Highly Cited
2007
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites.
Sonic hedgehog (Shh) is a morphogen pivotal for development and tissue maintenance. Biological effects of Shh are mediated… Expand
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Highly Cited
2003
Highly Cited
2003
Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs.
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate various forms of urticaria by a nonallergic mechanism… Expand
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Review
2003
Review
2003
Benefit-Risk Assessment of Antileukotrienes in the Management of Asthma
Antileukotrienes are a relatively new class of anti-asthma drugs that either block leukotriene synthesis (5-lipoxygenase… Expand
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Review
2001
Review
2001
Antileukotrienes in asthma: present situation.
Leukotrienes are key mediators in asthma. Over the last 5 years, several antileukotrienes, including three receptor antagonists… Expand
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1999
1999
5-Lipoxygenase upregulation by dexamethasone in human mast cells.
In spite of intensive research, our understanding of the regulation of expression of 5-LO (the key enzyme in the leukotriene… Expand
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Highly Cited
1993
Highly Cited
1993
Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone.
The variation of the selenium status of leukocytes was used as a tool to investigate the influence of selenium-containing… Expand
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Highly Cited
1993
Highly Cited
1993
n-3 fatty acids and cysteinyl-leukotriene formation in humans in vitro, ex vivo, and in vivo.
In humans, dietary n-3 fatty acids ameliorate some chronic inflammatory diseases. In contrast, however, dietary n-3 fatty acids… Expand
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