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leukotriene metabolic process

Known as: leukotriene metabolism 
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Transcription Factor and Drug-Metabolizing Enzyme Gene Expression in Lymphocytes from Healthy Human Subjects
We aimed to measure simultaneously the expression of drug-metabolizing enzymes (DME) and transcription factors (TF) with high… Expand
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Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… Expand
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Highly Cited
2007
Highly Cited
2007
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites.
Sonic hedgehog (Shh) is a morphogen pivotal for development and tissue maintenance. Biological effects of Shh are mediated… Expand
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Highly Cited
2003
Highly Cited
2003
Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs.
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate various forms of urticaria by a nonallergic mechanism… Expand
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Review
2003
Review
2003
Benefit-Risk Assessment of Antileukotrienes in the Management of Asthma
Antileukotrienes are a relatively new class of anti-asthma drugs that either block leukotriene synthesis (5-lipoxygenase… Expand
1999
1999
5-Lipoxygenase upregulation by dexamethasone in human mast cells.
In spite of intensive research, our understanding of the regulation of expression of 5-LO (the key enzyme in the leukotriene… Expand
Highly Cited
1993
Highly Cited
1993
Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone.
The variation of the selenium status of leukocytes was used as a tool to investigate the influence of selenium-containing… Expand
Highly Cited
1993
Highly Cited
1993
n-3 fatty acids and cysteinyl-leukotriene formation in humans in vitro, ex vivo, and in vivo.
In humans, dietary n-3 fatty acids ameliorate some chronic inflammatory diseases. In contrast, however, dietary n-3 fatty acids… Expand
Highly Cited
1988
Highly Cited
1988
Metabolism of leukotriene E4 in isolated rat hepatocytes. Identification of beta-oxidation products of sulfidopeptide leukotrienes.
Little is known about the metabolic fate of the sulfidopeptide leukotrienes (LTC4/D4/E4). Earlier studies using radiolabeled… Expand
Highly Cited
1984
Highly Cited
1984
Pharmacological evidence for a distinct leukotriene C4 receptor in guinea-pig trachea.
  • D. Snyder, R. Krell
  • The Journal of pharmacology and experimental…
  • 1984
    • Corpus ID: 24965603
The effect of the leukotriene (LT) antagonist, FPL55712, on the contractile activity of peptide leukotrienes was evaluated in the… Expand
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