S. Gibbons

Publications234
h-index46
Citations7,723
Highly Influential Citations278
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Anti-staphylococcal plant natural products.
  • S. Gibbons
  • Biology, Medicine
  • Natural product reports
  • 23 March 2004
Covering: 1995 to 2003 The occurrence of vancomycin-resistant Staphylococcus aureus (VRSA) and multidrug-resistant (MDR) strains of this organism necessitate the discovery of new classes of… Expand
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Bacterial efflux pump inhibitors from natural sources.
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial… Expand
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The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor
In this paper we determined the pharmacological profiles of novel ketamine and phencyclidine analogues currently used as ‘designer drugs’ and compared them to the parent substances via the resources… Expand
  • 108
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Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids… Expand
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Phytochemicals for bacterial resistance--strengths, weaknesses and opportunities.
  • S. Gibbons
  • Biology, Medicine
  • Planta medica
  • 1 August 2007
This review covers some of the opportunities which currently exist to exploit plants for their natural products as templates for new antibacterial substances. This is a timely exercise given the… Expand
  • 208
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Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity.
The dichloromethane extract of the stem bark of Warburgia ugandensis afforded three new coloratane sesquiterpenes, namely: 6alpha,9alpha-dihydroxy-4(13),7-coloratadien-11,12-dial (1),… Expand
  • 71
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A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus.
GG918, a synthetic inhibitor of P-glycoprotein-mediated mammalian tumour multidrug resistance, was found to be equipotent to reserpine in enhancing the in vitro activity of norfloxacin and… Expand
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The Phenolic Diterpene Totarol Inhibits Multidrug Efflux Pump Activity in Staphylococcus aureus
ABSTRACT The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Subinhibitory concentrations reduced the MICs of selected antibiotics,… Expand
  • 103
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Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at… Expand
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Antibacterial and resistance modifying activity of Rosmarinus officinalis.
As part of a project to characterise plant-derived natural products that modulate bacterial multidrug resistance (MDR), bioassay-guided fractionation of a chloroform extract of the aerial parts of… Expand
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