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Anti-staphylococcal plant natural products.
- S. Gibbons
- BiologyNatural product reports
- 23 March 2004
The activities described here show that there are many potential new classes of anti-staphylococcal agents which should undergo further cytotoxicity, microbial specificity and preclinical in vivo studies to assess their potential.
Fundamentals of Pharmacognosy and Phytotherapy
- M. Heinrich, A. Foreword, J. D. P. epilogue, illustrations by Debbie Maizels, S. Gibbons
- Medicine, Biology
- 19 January 2004
Part A: Fundamentals of Pharmacology: Phytotherapy and Pharmacognosy shows importance in modern pharmacy and medicine and important natural products and Phytomedicines used in Pharmacy and Medicine.
Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties
- J. Barnes, L. A. Anderson, S. Gibbons, J. Phillipson
- BiologyThe Journal of pharmacy and pharmacology
- 1 August 2005
Evidence from preclinical studies supports some of the traditional and modern uses for echinacea, particularly the reputed immunostimulant (or immunomodulatory) properties, but evidence of efficacy is not definitive as studies have included different patient groups and tested various different preparations and dosage regimens.
Bacterial efflux pump inhibitors from natural sources.
The use of bacterial resistance modifiers such as EPIs could facilitate the re-introduction of therapeutically ineffective antibiotics back into clinical use such as ciprofloxacin and might even suppress the emergence of MDR strains.
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
Observations suggest that the prenyl moiety of cannabinoids serves mainly as a modulator of lipid affinity for the olivetol core, a per se poorly active antibacterial pharmacophore, while their high potency definitely suggests a specific, but yet elusive, mechanism of activity.
Neurochemical profiles of some novel psychoactive substances.
The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor
The novel ketamine and PCP analogues had significant affinities for the NMDA receptor in radioligand binding assays, which may explain their psychotomimetic effects in human users.
Phytochemicals for bacterial resistance--strengths, weaknesses and opportunities.
- S. Gibbons
- BiologyPlanta medica
- 1 August 2007
This review covers some of the opportunities which currently exist to exploit plants for their natural products as templates for new antibacterial substances. This is a timely exercise given the…
Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity.
Plants as a Source of Bacterial Resistance Modulators and Anti-Infective Agents
- S. Gibbons
- BiologyPhytochemistry Reviews
The activities of plant-derived antibacterials show that there are many potential new classes of antibacterial agents which should undergo further cytotoxicity, microbial specificity and preclinical studies.