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Discovery and resupply of pharmacologically active plant-derived natural products: A review
While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs in the future. Expand
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review
Graphical abstract
Alkamides from the roots of Echinacea purpurea
Abstract Five new alkylamides, undeca-2 E ,4 Z -dien-8,10-diynoic acid isobutylamide, dodeca-2 E ,4 Z -dien-8,10-diynoic acid isobutylamide, dodeca-2 E ,4 E ,10 E -trien-8-ynoic acid isobutylamide,Expand
TLC and HPLC Analysis of Alkamides in Echinacea Drugs1,2.
HPLC and TLC methods are presented for the analysis of the alkamides in ECHINACEA PURPUREA, E. ANGUSTIFOLIA, and E. PALLIDA, finding similar alkamide patterns in the roots and aerial parts of the three species. Expand
The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots.
Most of the alkamides showed good metabolic stability as indicated by the similarity between affinity to CB1 determined in the presence/absence of the protease inhibitor PMSF, and it is suggested that CB2 interactions may be the molecular mode of action of Echinacea alkamide as immunomodulators. Expand
Alkamides from the roots of Echinacea angustifolia
Abstract The isolation and structure elucidation of 15 alkamides from the roots of Echinacea angustifolia is reported. In addition to several compounds previously found in E. purpurea the newExpand
An evaluation of Echinacea angustifolia in experimental rhinovirus infections.
The results of this study indicate that extracts of E. angustifolia root, either alone or in combination, do not have clinically significant effects on infection with a rhinovirus or on the clinical illness that results from it. Expand
Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats.
The results suggest that the alkylamides are one of the active constituents of E. purpurea plant that effectively stimulate alveolar macrophage function in healthy rats and appear to be more pronounced in lungs than in spleen. Expand
MEKC analysis of different Echinacea species.
Evidence is obtained that MEKC is a valuable tool for the characterization of these drugs. Expand