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leucine biosynthetic process

Known as: leucine anabolism, leucine formation, leucine biosynthesis 
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. [GOC:ai]
National Institutes of Health

Papers overview

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2009
2009
A redox-active isopropylmalate dehydrogenase functions in the biosynthesis of glucosinolates and leucine in Arabidopsis.
We report a detailed functional characterization of an Arabidopsis isopropylmalate dehydrogenase (AtIPMDH1) that is involved in… Expand
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Highly Cited
2007
Highly Cited
2007
DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Deltasnf2 disruptant of Saccharomyces cerevisiae.
We previously found that SNF2, a gene encoding a transcription factor forming part of the SWI/SNF (switching/sucrose non… Expand
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Highly Cited
2004
Highly Cited
2004
Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis.
The leucine biosynthetic pathway is essential for the growth of Mycobacterium tuberculosis and is a potential target for the… Expand
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1997
1997
Putative evolutionary origin of plasmids carrying the genes involved in leucine biosynthesis in Buchnera aphidicola (endosymbiont of aphids).
An 8.5-kb plasmid encoding genes (leuABCD) involved in leucine biosynthesis and a small plasmid of 1.74 kb of yet unknown… Expand
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1992
1992
Lambda placMu insertions in genes of the leucine regulon: extension of the regulon to genes not regulated by leucine.
The leucine regulon coordinates the expression of several Escherichia coli genes according to the presence of exogenous leucine… Expand
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1988
1988
LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence.
LEU3 of Saccharomyces cerevisiae encodes an 886-amino-acid polypeptide that regulates transcription of a group of genes involved… Expand
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Highly Cited
1985
Highly Cited
1985
Leucine incorporation and its potential as a measure of protein synthesis by bacteria in natural aquatic systems.
Leucine incorporation was examined as a method for estimating rates of protein synthesis by bacterial assemblages in natural… Expand
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1984
1984
High guanine plus cytosine content in the third letter of codons of an extreme thermophile. DNA sequence of the isopropylmalate dehydrogenase of Thermus thermophilus.
In studies on the cause of the extreme stability of the macromolecules of Thermus thermophilus HB8, the leuB gene coding for 3… Expand
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1973
1973
Genetic studies of leucine biosynthesis in Bacillus subtilis.
The mutations in a series of leucine auxotrophs isolated after treatment with nitrosoguanidine, ultraviolet light, and ICR-191… Expand
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1962
1962
Control of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression.
 
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