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leucine biosynthetic process

Known as: leucine anabolism, leucine formation, leucine biosynthesis 
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. [GOC:ai]
National Institutes of Health

Papers overview

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2007
2007
Connecting primary and secondary metabolism: AreB, an IclR‐like protein, binds the AREccaR sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid…
A protein binding to the autoregulatory element (ARE) upstream of the regulatory ccaR gene of Streptomyces clavuligerus was… 
2000
2000
Identification of Enzymes Homologous to Isocitrate Dehydrogenase That Are Involved in Coenzyme B and Leucine Biosynthesis in Methanoarchaea
ABSTRACT Two putative Methanococcus jannaschii isocitrate dehydrogenase genes, MJ1596 and MJ0720, were cloned and overexpressed… 
Highly Cited
1997
Highly Cited
1997
Putative evolutionary origin of plasmids carrying the genes involved in leucine biosynthesis in Buchnera aphidicola (endosymbiont of aphids)
An 8.5-kb plasmid encoding genes (leuABCD) involved in leucine biosynthesis and a small plasmid of 1.74 kb of yet unknown… 
Highly Cited
1996
Highly Cited
1996
Neuronal Metabolism of Branched‐Chain Amino Acids: Flux Through the Aminotransferase Pathway in Synaptosomes
Abstract: The metabolism of branched‐chain amino acids (BCAAs) was studied in cortical synaptosomes. With [15N]leucine (1 mM) as… 
Highly Cited
1984
Highly Cited
1984
High guanine plus cytosine content in the third letter of codons of an extreme thermophile. DNA sequence of the isopropylmalate dehydrogenase of Thermus thermophilus.
1978
1978
Role of the Escherichia coli aromatic amino acid aminotransferase in leucine biosynthesis
Strains of Escherichia coli that lack the branched-chain amino acid amino-transferase because of mutations in the ilvE gene had… 
Highly Cited
1969
Highly Cited
1969
Regulation of Branched-Chain Amino Acid Biosynthesis in Salmonella typhimurium: Isolation of Regulatory Mutants
5′,5′,5′-Trifluoro-dl-leucine inhibited the activity of α-isopropylmalate synthetase (the initial enzyme unique to leucine… 
1969
1969
A Salmonella typhimurium locus involved in the regulation of isoleucine, valine and leucine biosynthesis.
HE genes determining the enzymes of isoleucine and valine biosynthesis in Escherichia coli and Salmonella typhimurium are… 
Highly Cited
1962
Highly Cited
1962
Control of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression.
Repression of the formation of biosynthetic enzymes by the ultimate end product of their action has been shown to be an important… 
1962
1962
Another intermediate in leucine biosynthesis.
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