• Publications
  • Influence
A large family of bacterial activator proteins.
TLDR
The combined evidence indicates that all nine proteins in the LysR family are related by common ancestry, are similarly folded, and are not detectably related to other known bacterial regulatory proteins.
The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli.
TLDR
The leucine-responsive regulatory protein (Lrp) regulates the expression of more than 40 genes and proteins in Escherichia coli, and seems to be important in regulating nitrogen metabolism and one-carbon metabolism, permitting adaptations to feast and to famine.
The ilvIH operon of Escherichia coli is positively regulated
TLDR
Results indicate that the IHB protein is a positive regulator of ilvIH operon expression and propose that the designation lrp (leucine-responsive regulatory protein) be used in place of IHB.
Compounds Which Serve as the Sole Source of Carbon or Nitrogen for Salmonella typhimurium LT-2
About 600 compounds were screened as possible carbon or nitrogen sources for Salmonella typhimurium LT-2. About 100 utilizable compounds were found.
Lrp, a global regulatory protein of Escherichia coli, binds co-operatively to multiple sites and activates transcription of ilvIH.
TLDR
A model in which multiple binding sites contribute to the formation of a nucleoprotein complex, but only a particular proximal site positions Lrp properly so that it interacts with RNA polymerase is proposed.
A consensus sequence for binding of Lrp to DNA
TLDR
A consensus sequence derived from analysis of 63 related DNA sequences that bound Lrp, YAGHAWATTWT DCTR, contains clear dyad symmetry and is very similar to the one defined earlier.
Leucine-responsive regulatory protein controls the expression of both the pap and fan pili operons in Escherichia coli.
TLDR
Analysis of the mbf gene indicates that it is identical to a recently described global regulatory gene lrp (leucine-responsive regulatory protein) that acts as a positive regulator of some genes and a negative regulator of others in E. coli, and it is shown that Lrp positively regulates transcription of the fan operon, which encodes K99 pili of diarrheagenic E coli.
Mutations affecting the ability of Escherichia coli Lrp to bind DNA, activate transcription, or respond to leucine
TLDR
This study suggests that Lrp has separate domains responsible for binding DNA, activating transcription, and responding to leucine, which is similar to other regulatory proteins in Escherichia coli.
Effects of nutrition and growth rate on Lrp levels in Escherichia coli
TLDR
The levels of lrp expression were the same or slightly higher in strains containing mutations in rpoS, cya, or crp compared with wild-type strains, suggesting that neither RpoS nor the cyclic AMP (cAMP) receptor protein-cAMP complex is required for expression.
Transcriptional regulation of the ilv-leu operon of Bacillus subtilis
TLDR
Analysis of primer extension and mutational analysis of RNA synthesized in vivo showed that the steady-state level of mRNA upstream of the terminator was twofold higher from cells limited for leucine than it was from cells grown with excessLeucine, demonstrating that the ilv-leu operon is regulated by transcription attenuation.
...
...