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The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus.
Site-directed mutagenesis was used to create 91 single mutant clones of vesicular stomatitis virus derived from a common ancestral cDNA and competition experiments to measure the relative fitness of each mutant.
The Gypsy Database (GyDB) of mobile genetic elements: release 2.0
The second release of the Gypsy Database of Mobile Genetic Elements (GyDB 2.0) is introduced, an update based on the analysis of Ty3/Gypsy, Retroviridae, Ty1/Copia and Bel/Pao LTR retroelements and the Caulimoviridae pararetroviruses of plants.
High Diversity of the Viral Community from an Antarctic Lake
The genetic structure of an Antarctic lake viral community revealed unexpected genetic richness distributed across the highest number of viral families that have been found to date in aquatic viral metagenomes, in contrast to other known aquatic viromes.
Immunity and other defenses in pea aphids, Acyrthosiphon pisum
It is suggested that several aspects of the aphid life style, such as their association with microbial symbionts, could facilitate survival without strong immune protection, and the traditional view of insect immunity may not be as broadly applicable as once thought.
A Small Microbial Genome: The End of a Long Symbiotic Relationship?
The 422,434–base pair genome of Buchnera aphidicola BCc, primary endosymbiont of the aphid Cinara cedri, is ∼200 kilobases smaller than the previously sequenced B. aphidICola genomes, suggesting that B. Aphidicolas is losing its symbiotic capacity and is being complemented (and might be replaced) by the highly abundant coexisting secondary symbiont.
Learning how to live together: genomic insights into prokaryote–animal symbioses
Our understanding of prokaryote–eukaryote symbioses as a source of evolutionary innovation has been rapidly increased by the advent of genomics, which has made possible the biological study of
Side‐stepping secondary symbionts: widespread horizontal transfer across and beyond the Aphidoidea
Findings on the prevalence of these symbionts within many aphid taxa, along with published observations concerning their effects on host fitness, imply a significant role of facultative symbiosis in aphid ecology and evolution.
The genome sequence of Blochmannia floridanus: Comparative analysis of reduced genomes
The phylogenetic analysis of a set of conserved protein-coding genes shows that Bl.
Determination of the Core of a Minimal Bacterial Gene Set
A computational comparative analysis of eight bacterial genomes was performed, and the proposed minimal genome contains 206 protein-coding genes with all the genetic information necessary for self-maintenance and reproduction in the presence of a full complement of essential nutrients and in the absence of environmental stress.
The contribution of epistasis to the architecture of fitness in an RNA virus.
The results show that the architecture of the fitness depends on complex interactions among genome components, including antagonistic and synergistic epistasis.