letrozole

Known as: Letrozol, letrozole [Chemical/Ingredient], Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis- 
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and… (More)

Topic mentions per year

Topic mentions per year

1989-2017
010020019892017

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Palbociclib (PD-0332991) is an oral, small-molecule inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 with… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Cross-talk between human epidermal growth factor receptors and hormone receptor pathways may cause endocrine resistance… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Cross-talk between the estrogen receptor (ER) and the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamycin… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Previous analyses of the Breast International Group (BIG) 1-98 four-arm study compared initial therapy with letrozole or… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND The aromatase inhibitor letrozole is a more effective treatment for metastatic breast cancer and more effective in the… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Most recurrences in women with breast cancer receiving 5 years of adjuvant tamoxifen occur after 5 years. The MA.17… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND In hormone-dependent breast cancer, five years of postoperative tamoxifen therapy--but not tamoxifen therapy of longer… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE Expression of ErbB-1 and ErbB-2 (epidermal growth factor receptor and HER2/neu) in breast cancer may cause tamoxifen… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE To compare the efficacy and tolerability of tamoxifen with that of letrozole, an oral aromatase inhibitor, with tamoxifen… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND A randomized, double-blind, multicenter study was conducted to compare the anti-tumor activity of letrozole vs… (More)
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