lactacystin
National Institutes of Health
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Although inhibition of the ubiquitin proteasome system has been postulated to play a key role in the pathogenesis of…
Although tumor necrosis factor (TNF)-α is implicated in numerous cardiac pathologies, the intracellular events leading to its…
A selective, irreversible inhibitor of proteasome function, lactacystin (1) is an important experimental tool in cell biology. An…
Intercellular communication may be modulated by the rather rapid turnover and degradation of gap junction proteins, since many…
Lactacystin, originally isolated from a microbe as an inducer of neuritogenesis, targets the catalytic beta-subunit of the…