lactacystin

 
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important cellular mechanisms… (More)
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Highly Cited
2007
Highly Cited
2007
Dysfunction of the ubiquitin-proteasome system (UPS) and accumulation of iron in substantia nigra (SN) are implicated in the… (More)
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Highly Cited
2002
Highly Cited
2002
Protein conformational disorders (PCDs), such as Alzheimer's disease, Huntington's disease (HD), Parkinson's disease and… (More)
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Highly Cited
1999
Highly Cited
1999
The proteasome regulates cellular processes as diverse as cell cycle progression and NF-kappaB activation. In this study, we show… (More)
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Highly Cited
1997
Highly Cited
1997
The antibiotic lactacystin was reported to covalently modify beta-subunit X of the mammalian 20 S proteasome and inhibit several… (More)
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Highly Cited
1997
Highly Cited
1997
The natural product lactacystin exerts its cellular antiproliferative effects through a mechanism involving acylation and… (More)
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1997
1997
Lactacystin, the most specific inhibitor of the proteasome, strongly inhibited at pH 5.5 the activity of human platelet lysosomal… (More)
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Highly Cited
1996
Highly Cited
1996
Lactacystin is a Streptomyces metabolite that inhibits cell cycle progression and induces differentiation in a murine… (More)
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Highly Cited
1995
Highly Cited
1995
Lactacystin is a Streptomyces metabolite that inhibits cell cycle progression and induces neurite outgrowth in a murine… (More)
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Highly Cited
1995
Highly Cited
1995
The molecular components of the quality control system that rapidly degrades abnormal membrane and secretory proteins have not… (More)
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