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ispinesib
A synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein…
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National Institutes of Health
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Related topics
Related topics
9 relations
Broader (2)
Benzamides
Quinazolines
CK0238273
Ispinesib Mesylate
KIF11 protein, human
NCIt Antineoplastic Agent Terminology
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Narrower (1)
SB 715992
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Malaria: New target for vaccine development
Megan Cully
Nature reviews. Drug discovery
2014
Corpus ID: 1048992
Two new papers describe the incorporation of the CRISPR–Cas9 (clustered regularly interspaced short palindromic repeats–Cas9…
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2014
2014
Synthesis, docking studies, and in silico ADMET predictions of some new derivatives of pyrimidine as potential KSP inhibitors
Umer Rashid
,
S. Hassan
,
S. Nazir
,
A. Wadood
,
M. Waseem
,
F. Ansari
Medicinal Chemistry Research
2014
Corpus ID: 253638393
The guanidine functionality has been found in numerous biologically active natural products and several drugs. We have, therefore…
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2013
2013
Survival in Head and Neck and Lung Cancer Functional Genetic Screens Identify Genes Essential for Tumor Cell
S. R. M. Kemp
,
Remco Nagel
,
+4 authors
R. Brakenhoff
2013
Corpus ID: 7383716
Purpose: Despite continuous improvement of treatment regimes, the mortality rates for non–small cell lung cancer (NSCLC) and head…
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2013
2013
Smooth muscle cell proliferation and endothelin pathway in pulmonary arterial hypertension : comparative effects of current and putative therapeutic agents
J. Patel
2013
Corpus ID: 57551469
Pulmonary arterial hypertension (PAH) is characterised by a progressive increase in pulmonary vascular resistance (PVR) leading…
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2013
2013
Conformational Changes in the Mitotic ' ' Snapshots ' ' of Ispinesib-induced Protein Structure and Folding :
S. Rosenfeld
,
K. Tkocz
,
F. Kozielski
,
Steven
,
H. Kaan
,
J. Major
2013
Corpus ID: 207770171
2012
2012
Structural and functional characterisation of conventional kinesin and mitotic kinesin Eg5 — a validated target for cancer chemotherapy
H. Kaan
2012
Corpus ID: 82785873
Kinesins are molecular motors that use energy from ATP hydrolysis to transport cargoes along microtubule tracks. There are at…
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2010
2010
Abstract 5422: Drug combination studies in a panel of 30 cell lines established from patient-derived tumor xenograft
G. Kelter
,
V. Smith
,
T. Metz
,
H. Fiebig
,
T. Beckers
2010
Corpus ID: 75751277
In recent years, the focus of anticancer drug development has changed from conventional cytotoxic drugs to targeted agents…
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2008
2008
A phase I-II open-label trial of ispinesib on an alternate dosing schedule in chemotherapy-naive patients with locally advanced or metastatic breast cancer (MBC)
M. Philco
,
S. Falcón
,
H. Gómez
,
R. Escandon
,
K. Saikali
,
A. Wolff
2008
Corpus ID: 78351526
1143 Background: Kinesin spindle protein (KSP) is a mitotic kinesin essential for cell cycle progression. Ispinesib, a selective…
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2008
2008
Pediatric phase I trial and pharmacokinetic (PK) study of ispinesib (SB715992): A Children’s Oncology Group phase I consortium study
A. Souid
,
R. Dubowy
,
+4 authors
P. Adamson
2008
Corpus ID: 74489086
10014 Background: Ispinesib is a highly specific inhibitor of kinesin spindle protein (KSP), a member of the kinesin superfamily…
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2005
2005
Phase II, open label study of SB-715992 (Ispinesib) in subjects with advanced or metastatic breast cancer
K. Miller
,
C. Ng
,
+13 authors
P. Ho
2005
Corpus ID: 113925019