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ispinesib
A synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein…
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National Institutes of Health
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Related topics
Related topics
9 relations
Broader (2)
Benzamides
Quinazolines
CK0238273
Ispinesib Mesylate
KIF11 protein, human
NCIt Antineoplastic Agent Terminology
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Narrower (1)
SB 715992
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Synthesis, docking studies, and in silico ADMET predictions of some new derivatives of pyrimidine as potential KSP inhibitors
Umer Rashid
,
S. Hassan
,
S. Nazir
,
A. Wadood
,
M. Waseem
,
F. Ansari
Medicinal Chemistry Research
2014
Corpus ID: 253638393
The guanidine functionality has been found in numerous biologically active natural products and several drugs. We have, therefore…
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2014
2014
Malaria: New target for vaccine development
Megan Cully
Nature reviews. Drug discovery
2014
Corpus ID: 1048992
Two new papers describe the incorporation of the CRISPR–Cas9 (clustered regularly interspaced short palindromic repeats–Cas9…
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2013
2013
Survival in Head and Neck and Lung Cancer Functional Genetic Screens Identify Genes Essential for Tumor Cell
S. R. M. Kemp
,
Remco Nagel
,
+4 authors
R. Brakenhoff
2013
Corpus ID: 7383716
Purpose: Despite continuous improvement of treatment regimes, the mortality rates for non–small cell lung cancer (NSCLC) and head…
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2013
2013
Smooth muscle cell proliferation and endothelin pathway in pulmonary arterial hypertension : comparative effects of current and putative therapeutic agents
J. Patel
2013
Corpus ID: 57551469
Pulmonary arterial hypertension (PAH) is characterised by a progressive increase in pulmonary vascular resistance (PVR) leading…
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2012
2012
Structural and functional characterisation of conventional kinesin and mitotic kinesin Eg5 — a validated target for cancer chemotherapy
H. Kaan
2012
Corpus ID: 82785873
Kinesins are molecular motors that use energy from ATP hydrolysis to transport cargoes along microtubule tracks. There are at…
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2009
2009
A phase I-II trial ofIspinesib, a kinesin spindle protein inhibitor, dosed every two weeks in patients with locally advanced or metastatic breast cancer previously untreated with chemotherapy for…
H. Gómez
,
C. Castañeda
,
+7 authors
A. Wolff
2009
Corpus ID: 75665661
CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts Abstract #2148 Kinesin Spindle Protein (KSP) is a mitotic…
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2009
2009
A Phase I-II Trial of Ispinesib, a Kinesin Spindle Protein Inhibitor, Dosed Every Two Weeks as First Line Chemotherapy for Advanced Locally Recurrent or Metastatic Breast Cancer.
H. Gómez
,
M. Philco
,
+5 authors
M. Conlan
2009
Corpus ID: 71978387
Background: Kinesin Spindle Protein (KSP) is a mitotic kinesin essential for cell cycle progression. Ispinesib , a selective KSP…
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2008
2008
A phase I-II open-label trial of ispinesib on an alternate dosing schedule in chemotherapy-naive patients with locally advanced or metastatic breast cancer (MBC)
M. Philco
,
S. Falcón
,
H. Gómez
,
R. Escandon
,
K. Saikali
,
A. Wolff
2008
Corpus ID: 78351526
1143 Background: Kinesin spindle protein (KSP) is a mitotic kinesin essential for cell cycle progression. Ispinesib, a selective…
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2008
2008
Pediatric phase I trial and pharmacokinetic (PK) study of ispinesib (SB715992): A Children’s Oncology Group phase I consortium study
A. Souid
,
R. Dubowy
,
+4 authors
P. Adamson
2008
Corpus ID: 74489086
10014 Background: Ispinesib is a highly specific inhibitor of kinesin spindle protein (KSP), a member of the kinesin superfamily…
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2005
2005
Phase II, open label study of SB-715992 (Ispinesib) in subjects with advanced or metastatic breast cancer
K. Miller
,
C. Ng
,
+13 authors
P. Ho
2005
Corpus ID: 113925019