• Publications
  • Influence
Kinesins and cancer
Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few yearsExpand
The Crystal Structure of Dimeric Kinesin and Implications for Microtubule-Dependent Motility
The dimeric form of the kinesin motor and neck domain from rat brain with bound ADP has been solved by X-ray crystallography. The two heads of the dimer are connected via a coiled-coil alpha-helicalExpand
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.
Human Eg5, a member of the kinesin superfamily, plays a key role in mitosis, as it is required for the formation of a bipolar spindle. We describe here the first in vitro microtubule-activatedExpand
S-Trityl-L-cysteine Is a Reversible, Tight Binding Inhibitor of the Human Kinesin Eg5 That Specifically Blocks Mitotic Progression*
Human Eg5, responsible for the formation of the bipolar mitotic spindle, has been identified recently as one of the targets of S-trityl-l-cysteine, a potent tumor growth inhibitor in the NCI 60 tumorExpand
The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition
A tail domain autoinhibits a dimeric kinesin by preventing relative movement of the two motor domains. When not transporting cargo, kinesin-1 is autoinhibited by binding of a tail region to the motorExpand
Motor-dependent microtubule disassembly driven by tubulin tyrosination
In cells, stable microtubules (MTs) are covalently modified by a carboxypeptidase, which removes the C-terminal Tyr residue of α-tubulin. The significance of this selective detyrosination of MTs isExpand
Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.
Human Eg5, a mitotic motor of the kinesin superfamily, is involved in the formation and maintenance of the mitotic spindle. The recent discovery of small molecules that inhibit HsEg5 by binding toExpand
Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.
The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows a three-domain structure with an N-terminal motor domain, a centralExpand
Structure of Human Eg5 in Complex with a New Monastrol-based Inhibitor Bound in the R Configuration*
Drugs that target mitotic spindle proteins have been proven useful for tackling tumor growth. Eg5, a kinesin-5 family member, represents a potential target, since its inhibition leads to prolongedExpand
Kinesin-12, a Mitotic Microtubule-Associated Motor Protein, Impacts Axonal Growth, Navigation, and Branching
Kinesin-12 (also called Kif15) is a mitotic motor protein that continues to be expressed in developing neurons. Depletion of kinesin-12 causes axons to grow faster, more than doubles the frequency ofExpand