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iproplatin

Known as: (OC-6-33)-dichlorodihydroxybis(2-propanamine)platinum, CHIP, Platinum, dichlorodihydroxybis(2-propanamine)-, (oc-6-33)- 
A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA… Expand
National Institutes of Health

Papers overview

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1996
1996
The combination of VP‐16 and cisplatin is one of the most active regimens available for the treatment of small cell lung cancer… Expand
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Highly Cited
1993
Highly Cited
1993
The in vitro cytotoxicity, protein binding, partitioning of platinum from whole blood into erythrocytes, its exchange back into… Expand
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Highly Cited
1992
Highly Cited
1992
PURPOSE The Pediatric Oncology Group (POG) conducted a randomized phase II study to evaluate the activity of carboplatin and… Expand
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Highly Cited
1989
Highly Cited
1989
During the last decade, the Eastern Cooperative Oncology Group (ECOG) has studied a series of combination chemotherapy regimens… Expand
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Highly Cited
1989
Highly Cited
1989
A total of 394 patients with advanced, measurable squamous carcinoma of the uterine cervix and no prior chemotherapy were… Expand
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Highly Cited
1988
Highly Cited
1988
Iproplatin is a quadrivalent second-generation platinum complex undergoing clinical evaluation. In plasma and urine of patients… Expand
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Highly Cited
1987
Highly Cited
1987
We have developed a human head and neck squamous cell carcinoma cell line (SCC-25/CP) which is relatively stably resistant to cis… Expand
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Highly Cited
1987
Highly Cited
1987
Human ovarian cancer cell lines with stable cisplatin resistance have been developed by chronic exposure of the parent cisplatin… Expand
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Highly Cited
1987
Highly Cited
1987
The stability of cisplatin, iproplatin, carboplatin, and tetraplatin in common intravenous solutions was studied. Admixtures of… Expand
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Highly Cited
1985
Highly Cited
1985
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… Expand
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