iproplatin

Known as: (OC-6-33)-dichlorodihydroxybis(2-propanamine)platinum, CHIP, Platinum, dichlorodihydroxybis(2-propanamine)-, (oc-6-33)- 
A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA… (More)
National Institutes of Health

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Highly Cited
1992
Highly Cited
1992
PURPOSE The Pediatric Oncology Group (POG) conducted a randomized phase II study to evaluate the activity of carboplatin and… (More)
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Highly Cited
1992
Highly Cited
1992
The role of glutathione (GSH) in the effectiveness of and resistance to 7 platinum compounds [5 Pt(II) and 2 Pt(IV) drugs] was… (More)
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1990
1990
The quadrivalent second-generation platinum complex iproplatin and an in vivo divalent metabolite of iproplatin,cis-dichloro-bis… (More)
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Highly Cited
1989
Highly Cited
1989
During the last decade, the Eastern Cooperative Oncology Group (ECOG) has studied a series of combination chemotherapy regimens… (More)
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1989
1989
We have previously shown that a significant portion of the total platinum in the plasma of patients receiving iproplatin is… (More)
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1988
1988
Iproplatin is a quadrivalent second-generation platinum complex undergoing clinical evaluation. In plasma and urine of patients… (More)
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Highly Cited
1987
Highly Cited
1987
Human ovarian cancer cell lines with stable cisplatin resistance have been developed by chronic exposure of the parent cisplatin… (More)
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1987
1987
We compared the acute tubular nephrotoxicity of three platinum compounds in children and adults with solid tumors by monitoring… (More)
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1987
1987
The stability of cisplatin, iproplatin, carboplatin, and tetraplatin in common intravenous solutions was studied. Admixtures of… (More)
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Highly Cited
1985
Highly Cited
1985
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… (More)
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