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iproplatin

Known as: (OC-6-33)-dichlorodihydroxybis(2-propanamine)platinum, CHIP, Platinum, dichlorodihydroxybis(2-propanamine)-, (oc-6-33)- 
A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Antineoplastic AgentsCross-Linking ReagentsOrganoplatinum Compounds

Narrower (1)

JM9
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1996
Review
1996
Mutagenic and carcinogenic properties of platinum-based anticancer drugs.
Review
1993
Review
1993
Erratum to: Cyclosporin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Use in Immunoregulatory Disorders
Abstract Cyclosporin is a lipophilic cyclic polypeptide which produces calcium-dependent, specific, reversible inhibition of… 
Highly Cited
1993
Highly Cited
1993
In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin.
The in vitro cytotoxicity, protein binding, partitioning of platinum from whole blood into erythrocytes, its exchange back into… 
Highly Cited
1992
Highly Cited
1992
Characterization of high mobility group protein binding to cisplatin-damaged DNA.
Review
1990
Review
1990
Analytical methodologies for the quantitation of platinum anti-cancer drugs and related compounds in biological media.
Highly Cited
1989
Highly Cited
1989
Combination chemotherapy versus single agents followed by combination chemotherapy in stage IV non-small-cell lung cancer: a study of the Eastern Cooperative Oncology Group.
During the last decade, the Eastern Cooperative Oncology Group (ECOG) has studied a series of combination chemotherapy regimens… 
Highly Cited
1989
Highly Cited
1989
A randomized comparative trial of carboplatin and iproplatin in advanced squamous carcinoma of the uterine cervix: a Gynecologic Oncology Group study.
A total of 394 patients with advanced, measurable squamous carcinoma of the uterine cervix and no prior chemotherapy were… 
Highly Cited
1988
Highly Cited
1988
Identification of cis-dichloro-bis-isopropylamine platinum(II) as a major metabolite of iproplatin in humans.
Iproplatin is a quadrivalent second-generation platinum complex undergoing clinical evaluation. In plasma and urine of patients… 
Highly Cited
1987
Highly Cited
1987
Stability of cisplatin, iproplatin, carboplatin, and tetraplatin in commonly used intravenous solutions.
The stability of cisplatin, iproplatin, carboplatin, and tetraplatin in common intravenous solutions was studied. Admixtures of… 
Highly Cited
1985
Highly Cited
1985
Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.
We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… 
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