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Abstract Cyclosporin is a lipophilic cyclic polypeptide which produces calcium-dependent, specific, reversible inhibition of… Expand The in vitro cytotoxicity, protein binding, partitioning of platinum from whole blood into erythrocytes, its exchange back into… Expand PURPOSE
The Pediatric Oncology Group (POG) conducted a randomized phase II study to evaluate the activity of carboplatin and… Expand A total of 394 patients with advanced, measurable squamous carcinoma of the uterine cervix and no prior chemotherapy were… Expand During the last decade, the Eastern Cooperative Oncology Group (ECOG) has studied a series of combination chemotherapy regimens… Expand Iproplatin is a quadrivalent second-generation platinum complex undergoing clinical evaluation. In plasma and urine of patients… Expand We have developed a human head and neck squamous cell carcinoma cell line (SCC-25/CP) which is relatively stably resistant to cis… Expand Human ovarian cancer cell lines with stable cisplatin resistance have been developed by chronic exposure of the parent cisplatin… Expand The stability of cisplatin, iproplatin, carboplatin, and tetraplatin in common intravenous solutions was studied. Admixtures of… Expand We have determined the effect of glutathione (GSH) depletion on the cytotoxicity of three nitrogen mustards, six platinum… Expand