Zolpidem. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential.
While zolpidem aids sedation, and may reduce memory or psychomotor function within the first 2 hours after administration of single oral doses, its use as a surgical premedicant remains to be established.
Venlafaxine. A review of its pharmacology and therapeutic potential in depression.
Wider clinical experience is required to better characterise and confirm potential advantages of venlafaxine compared with other antidepressant agents, which may include a rapid onset of action and reduced propensity to cause anticholinergic effects and cardiotoxicity compared with tricyclic antidepressants.
Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
Fluoxetine has overall therapeutic efficacy comparable with imipramine, amitriptyline and doxepin in patients with unipolar depression treated for 5 to 6 weeks, although it may be less effective than tricyclic antidepressants in relieving sleep disorders in depressed patients.
Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.
The steroid-sparing effect of cyclosporin is a significant advantage in a number of indications, and the drug can be considered as a first line therapy in patients with moderate or severe aplastic anaemia who are ineligible for bone marrow transplantation, with the additional benefit of reducing platelet alloantibody titres.
Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing.
Hyaluronic acid is a well-established adjunct to cataract surgery and may prove to be a promising option in the treatment of patients with osteoarthritis, and its very good tolerability provides further impetus for examination of its potential role in an extended scope of arthritic and ophthalmological indications, and in wound healing.
A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy in the Management of Schizophrenia
Various sections of the manuscript reviewed by: w. T. Carpenter Tr, Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland, USA; Y. Lecrubier, Psychopathologie et…
Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
In patients with depressive illness, fluvoxamine offers a suitable alternative to tricyclic antidepressants and may be especially valuable in patients with concomitant cardiovascular disease, and those unresponsive to or unable to tolerate tricyClic antidepressants.
Topical mometasone. A review of its pharmacological properties and therapeutic use in the treatment of dermatological disorders.
Although mometasone demonstrates greater anti-inflammatory activity and a longer duration of action than betamethasone, it has low potential to cause adverse systemic effects such as suppression of the hypothalamic-pituitary-adrenal (HPA) axis.
Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.
- D. Campoli-Richards, J. Monk, A. Price, P. Benfield, P. A. Todd, A. Ward
- Medicine, BiologyDrugs
- 1 April 1988
As an orally active, broad spectrum and potent antibacterial drug, ciprofloxacin offers a valuable alternative to broad spectrum parenterally administered antibacterial drugs for use in a wide range of clinical infections, including difficult infections due to multiresistant pathogens.
Carboplatin. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of cancer.
Preliminary data suggest that carboplatin is a therapeutically equivalent alternative to cis platin, but with a differing toxicity profile that should offer advantages over cisplatin in many patients.