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interleukin-4-Pseudomonas exotoxin

Known as: interleukin-4-PE38KDEL cytotoxin, IL-4 PE38KDEL cytotoxin, IL4-Pseudomonas exotoxin 
A substance being studied in the treatment of cancer. It is made by combining interleukin-4 with a bacterial toxin. Interleukin-4 PE38KDEL… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Bacterial ToxinsExotoxinsInterleukin-4

Narrower (1)

NBI-3001

Papers overview

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Highly Cited
2015
Highly Cited
2015
Frequency of virulence factors in Helicobacter pylori-infected patients with gastritis.
2014
2014
Possible Association of IL-4 VNTR Polymorphism with Susceptibility to Preeclampsia
Preeclampsia (PE) is a pregnancy-specific disorder that results in maternal mortality and morbidity. Growing evidence indicated… 
2013
2013
The new allelic variant of the subtilase cytotoxin (subAB2) is common among Shiga toxin-producing Escherichia coli strains from large game animals and their meat and meat products.
2008
2008
Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab′) fragments
We reported previously the development of SMFv-PE38KDEL type I mutant (PE38KDEL-I; Mut-I), a recombinant immunotoxin in which a… 
2007
2007
Treatment of hepatocellular carcinoma in a mouse xenograft model with an immunotoxin which is engineered to eliminate vascular leak syndrome
Vascular leak syndrome (VLS) is the major dose-limiting toxicity of immunotoxin and interleukin-2 therapy. It has been evidenced… 
2006
2006
The Type III Pseudomonal Exotoxin U Activates the c-Jun NH2-Terminal Kinase Pathway and Increases Human Epithelial Interleukin-8 Production
ABSTRACT Microbial interactions with host cell signaling pathways are key determinants of the host cell response to infection… 
2005
2005
Recombinant Herpes Simplex Virus Type 1 (HSV-1) Codelivering Interleukin-12p35 as a Molecular Adjuvant Enhances the Protective Immune Response against Ocular HSV-1 Challenge
ABSTRACT An important aspect of ocular herpes simplex virus type 1 (HSV-1) vaccine development is identification of an… 
Highly Cited
2003
Highly Cited
2003
Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma.
PURPOSE This was an open-label, dose-escalation trial of intratumoral administration of IL-4 Pseudomonas Exotoxin (NBI-3001) in… 
Highly Cited
1998
Highly Cited
1998
Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.
No curative therapy is available for malignant gliomas. We have discovered that human glioblastoma cells express high affinity… 
Highly Cited
1989
Highly Cited
1989
Cytotoxic effect of multinucleation in HeLa cell cultures associated with the presence of Vir plasmid in Escherichia coli strains.
Escherichia coli strain S5 possesses a virulent plasmid termed Vir, which codes for a lethal toxin and a surface antigen. This… 
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