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Role of Tir and Intimin in the Virulence of Rabbit Enteropathogenic Escherichia coli Serotype O103:H2
TLDR
The role of intimin and its translocated coreceptor (Tir) in the pathogenicity of REPEC has been confirmed and it is shown, for the first time, that Tir is also a key factor in vivo for pathogenicicity. Expand
A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase
TLDR
This study demonstrates the mode of action of CDT and will help to elucidate the role of this emerging toxin family in microbial pathogenesis. Expand
Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle.
TLDR
The term "cyclomodulins" is proposed to describe the growing family of bacterial toxins and effectors that interfere with the eukaryotic cell cycle to delineate new perspectives in basic research and therapeutic applications. Expand
Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G2/M transition
TLDR
A new TTSS translocated effector molecule called Cif is identified, which blocks cell cycle G2/M transition and induces the formation of stress fibres through the recruitment of focal adhesions and is a new member of a growing family of bacterial cyclomodulins that subvert the host eukaryotic cell cycle. Expand
Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation
TLDR
It is demonstrated that CDT causes cell accumulation in G2 and not in M, that it does not slow the progression of cells through S phase, and that itdoes not affect the normal increase of cyclin B1 from late S to G2, while inhibitory activity was demonstrated for the three partially related CDTs. Expand
Necrotoxic Escherichia coli (NTEC): two emerging categories of human and animal pathogens.
TLDR
The combined production of several powerful toxins (haemolysin, CNF, CDT) by NTEC strains makes them, however, potentially aggressive pathogens which deserve to be searched for on a larger scale. Expand
Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation?
TLDR
The putative nuclease activity of CDT-B, together with the activation by CDT of a G2 cell cycle checkpoint, strongly suggests that CDT induces an as yet uncharacterized DNA alteration. Expand
Cytotoxins in non-enterotoxigenic strains of Escherichia coli isolated from feces of diarrheic calves.
TLDR
Seroneutralization assays showed that cytotoxins of the same type were closely related antigenically and a slight cross-neutralization was observed between Type 1 (CNF) and Type 2 (Vir) toxins. Expand
Comparison of necrotoxigenic Escherichia coli isolates from farm animals and from humans.
TLDR
It was thus possible neither to completely differentiate NTEC1 strains from cattle, humans, and pigs, nor to define a signature for the NTEC strains. Expand
Enteropathogenic Escherichia coli O103 from rabbit elicits actin stress fibers and focal adhesions in HeLa epithelial cells, cytopathic effects that are linked to an analog of the locus of enterocyte
TLDR
A new pathogenic trait of EPEC strains, which is associated with the LEE locus and, possibly, with in vivo virulence, is pointed to. Expand
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