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Enterohaemorrhagic Escherichia coli: emerging issues on virulence and modes of transmission.
Enterohaemorrhagic Escherichia coli (EHEC) constitute a subset of serotypes (E. coli O157 and some other serogroups) of Shiga toxin (Stx)-producing E. coli (STEC) firmly associated with severe humanExpand
Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells
Discovery of hybrid peptide-polyketide genotoxins in E. coli will change the view on pathogenesis and commensalism and open new biotechnological applications. Expand
Typing of Intimin Genes in Human and Animal Enterohemorrhagic and Enteropathogenic Escherichia coli: Characterization of a New Intimin Variant
The existence of a yet-unknown family of intimin was suspected because several EHEC strains, isolated from human and cattle, did not react with any of the specific primer pairs, although these strains were eaepositive when primers amplifying the conserved 5′ end were used. Expand
TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin‐cytoskeleton †
Results show that EHEC translocates both its own receptor (Tir) and an Nck‐like protein (TccP) to facilitate actin polymerization. Expand
Identification of the Secretion and Translocation Domain of the Enteropathogenic and Enterohemorrhagic Escherichia coli Effector Cif, Using TEM-1 β-Lactamase as a New Fluorescence-Based Reporter
The results demonstrate that Cif is composed of a C-terminal effector domain and an exchangeable N-Terminal translocation signal and that the TEM-1 reporter system is a convenient tool for the study of the translocation of toxins or effector proteins into host cells. Expand
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells
It is reported that in vivo infection with E. coli harboring the pks island, but not with a pks isogenic mutant, induced the formation of phosphorylated H2AX foci in mouse enterocytes, demonstrating the infection mutagenic and transforming potential. Expand
Role of Tir and Intimin in the Virulence of Rabbit Enteropathogenic Escherichia coli Serotype O103:H2
The role of intimin and its translocated coreceptor (Tir) in the pathogenicity of REPEC has been confirmed and it is shown, for the first time, that Tir is also a key factor in vivo for pathogenicicity. Expand
A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase
This study demonstrates the mode of action of CDT and will help to elucidate the role of this emerging toxin family in microbial pathogenesis. Expand
Production of Cytolethal Distending Toxins by Pathogenic Escherichia coli Strains Isolated from Human and Animal Sources: Establishment of the Existence of a New cdt Variant (Type IV)
A new PCR typing system for CDT able to detect a new CDT variant present in pathogenic E. coli strains obtained from animals and humans is developed. Expand
Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle.
The term "cyclomodulins" is proposed to describe the growing family of bacterial toxins and effectors that interfere with the eukaryotic cell cycle to delineate new perspectives in basic research and therapeutic applications. Expand