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interleukin 18 protein, human

Known as: IL-1g, Interleukin-18, IL-18, human 
Interleukin-18 (193 aa, ~22 kDa) is encoded by the human IL18 gene. This protein is involved in the regulation of both natural killer cell activity… Expand
National Institutes of Health

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Highly Cited
2001
Highly Cited
2001
IL-18, or IGIF (interferon-gamma inducing factor), is an IL-1-related, pro-inflammatory cytokine, which plays a pivotal role in… Expand
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Highly Cited
1997
Highly Cited
1997
We have previously reported the cloning of a novel cytokine, IFN-gamma-inducing factor (IGIF), which shared some biologic… Expand
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Highly Cited
1997
Highly Cited
1997
Interferon-γ-inducing factor (IGIF, interleukin-18) is a recently described cytokine that shares structural features with the… Expand
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Highly Cited
1997
Highly Cited
1997
In these studies, IFN gamma-inducing factor (IGIF), unlike IL-12, did not drive Th1 development in BALB/c or C57BL/6 mice, but… Expand
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Highly Cited
1997
Highly Cited
1997
The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory… Expand
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Highly Cited
1997
Highly Cited
1997
IL-12 and IFN-gamma-inducing factor (IGIF) have the capacity to stimulate IFN-gamma production by T cells. Using an IL-12… Expand
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Highly Cited
1996
Highly Cited
1996
We have recently reported that a novel molecule, murine IFN-gamma-inducing factor (IGIF) produced by mouse liver cells, possesses… Expand
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Highly Cited
1996
Highly Cited
1996
Fas ligand (FasL), expressed on activated T cells, plays a central role in regulating the immune response by inducing apoptosis… Expand
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Highly Cited
1995
Highly Cited
1995
THE mechanism underlying the differentiation of CD4+ T cells into functionally distinct subsets (Thl and Th2) is incompletely… Expand
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Highly Cited
1995
Highly Cited
1995
The mechanism underlying the differentiation of CD4+ T cells into functionally distinct subsets (Th1 and Th2) is incompletely… Expand
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