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interleukin 18 protein, human

Known as: IL-1g, Interleukin-18, IL-18, human 
Interleukin-18 (193 aa, ~22 kDa) is encoded by the human IL18 gene. This protein is involved in the regulation of both natural killer cell activity… 
National Institutes of Health

Related topics

Related topics

18 relations
Cell Proliferation Regulatory ProcessCytokine GeneCytokine Network PathwayCytokine Receptor Binding

Broader (1)

Interleukin-18

Papers overview

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Highly Cited
2001
Highly Cited
2001
IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.
IL-18, or IGIF (interferon-gamma inducing factor), is an IL-1-related, pro-inflammatory cytokine, which plays a pivotal role in… 
Review
1998
Review
1998
Overview of interleukin‐18: more than an interferon‐γ inducing factor
Initially described in 1989 as interferon‐γ (IFN‐γ) inducing factor (IGIF), interleukin‐18 (IL‐18) is a novel proinflammatory… 
Highly Cited
1998
Highly Cited
1998
Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis.
Specific oligonucleotide primers were used to identify and isolate IFN-gamma-inducing factor (IGIF) from the brain of rats with… 
Highly Cited
1998
Highly Cited
1998
Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme).
Procytokine processing by caspase-1 is required for the maturation and release of IL-1beta and IFN-gamma-inducing factor (IGIF… 
Highly Cited
1998
Highly Cited
1998
Interleukin‐18/interferon‐γ‐inducing factor, a novel cytokine, up‐regulates ICAM‐1 (CD54) expression in KG‐1 cells
Intercellular adhesion molecule‐1 (ICAM‐1, CD54) is a membrane glycoprotein and a member of the immunoglobulin superfamily. It… 
Highly Cited
1997
Highly Cited
1997
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.
In these studies, IFN gamma-inducing factor (IGIF), unlike IL-12, did not drive Th1 development in BALB/c or C57BL/6 mice, but… 
Highly Cited
1997
Highly Cited
1997
A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.
IL-12 and IFN-gamma-inducing factor (IGIF) have the capacity to stimulate IFN-gamma production by T cells. Using an IL-12… 
Highly Cited
1997
Highly Cited
1997
Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.
Recently, interferon-gamma-inducing-factor (IGIF) has been described as a novel monokine that is a more potent interferon-gamma… 
Highly Cited
1997
Highly Cited
1997
Induction of Interferon-γ Inducing Factor in the Adrenal Cortex*
Interferon-γ inducing factor (IGIF) is a recently identified cytokine also called interleukin-1γ (IL-1γ) or interleukin-18 (IL-18… 
Highly Cited
1996
Highly Cited
1996
Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production.
The novel cytokine interferon-gamma-inducing factor (IGIF) augments natural killer (NK) cell activity in cultures of human… 
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