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Interleukin-18

Known as: IFN-gamma Inducing Factor, Interferon-gamma Inducing Factor, IL18 
A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and… 
National Institutes of Health

Related topics

Related topics

15 relations
In BloodInterferon InducersInterleukin 18:MCnc:Pt:Ser/Plas:QnProcess of secretion

Narrower (2)

Recombinant Interleukin-18interleukin 18 protein, human

Broader (1)

cytokine

Papers overview

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Highly Cited
2009
Highly Cited
2009
Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury*
Ischemia/reperfusion (I/R) injury is characterized by the induction of oxidative stress and proinflammatory cytokine expression… 
Highly Cited
2005
Highly Cited
2005
Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis.
There are two distinct subtypes of multiple sclerosis in Asians, opticospinal (OS-multiple sclerosis) and conventional (C… 
Highly Cited
2002
Highly Cited
2002
Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E−/− Mice Through Release of Interferon-&ggr;
We have previously shown that interferon-&ggr; (IFN-&ggr;) is a potent enhancer of atherogenesis. Interleukin-18 (IL-18) promotes… 
Review
2002
Review
2002
Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity.
Highly Cited
2001
Highly Cited
2001
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production
Interleukin (IL)-18, initially described as interferon (IFN)-γ-inducing factor, is expressed in the inflamed mucosa of patients… 
Highly Cited
1999
Highly Cited
1999
IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils.
IL-18 is a proinflammatory cytokine that plays an important role in natural killer cell activation and T helper 1 (Th1) cell… 
Highly Cited
1992
Highly Cited
1992
Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection.
Nineteen individuals were studied for virologic and immunologic events during primary human immunodeficiency virus type 1 (HIV-1… 
Highly Cited
1988
Highly Cited
1988
Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes
To compare the helper function of murine T cell clones that secrete IL- 2 and IFN-gamma (Th1 cells) or IL-4 and IL-5 (Th2… 
Highly Cited
1979
Highly Cited
1979
In vitro transformation of cultured cells from Nicotiana tabacum by Agrobacterium tumefaciens
CROWN GALL, the plant tumour of many dicotyledonous and some monocotyledonous species, is caused by Agrobacterium tumefaciens… 
Highly Cited
1969
Highly Cited
1969
Isolation and Identification of Meiosis Inducing Substance in Starfish Asterias amurensis
INVESTIGATIONS of the mechanism of starfish spawning induced by injection of a water extract of radial nerves have shown that an… 
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