Interleukin-18

Known as: IFN-gamma Inducing Factor, Interferon-gamma Inducing Factor, IL18 
A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
OBJECTIVE Atherosclerosis is an inflammatory disease in which T helper 1 (Th1) immunity has been proposed to play an important… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND A single high-fat meal induces endothelial activation, which is associated with increased serum concentrations of… (More)
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Highly Cited
2002
Highly Cited
2002
We have previously shown that interferon-gamma (IFN-gamma) is a potent enhancer of atherogenesis. Interleukin-18 (IL-18) promotes… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Circulating levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) are elevated in diabetic… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND AND AIMS Persistent inflammation observed in inflammatory bowel disease may be the consequence of an increased or… (More)
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Review
2001
Review
2001
Although interleukin-18 is structurally homologous to IL-1 and its receptor belongs to the IL-1R/Toll-like receptor (TLR… (More)
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Review
2000
Review
2000
Innate immune response to microbes sometimes determines the nature of the following specific immune response. Kupffer cells, a… (More)
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Highly Cited
1999
Highly Cited
1999
Immunity to mycobacterial infection is closely linked to the emergence of T cells that secrete cytokines, gamma interferon (IFN… (More)
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Highly Cited
1998
Highly Cited
1998
IL-18 is synthesized as a precursor molecule without a signal peptide but requires the IL-1beta converting enzyme (ICE, caspase-1… (More)
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Highly Cited
1997
Highly Cited
1997
The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory… (More)
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