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Recombinant Interleukin-18

Known as: Interleukin-18, Interferon-Gamma-Inducing Factor, IL-18 
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-18 (IL-18). Produced primarily by… Expand
National Institutes of Health

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Related topics

7 relations
CXCL10 geneIL18 geneInhibition of Cell Proliferationinterleukin 18 protein, human
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Interleukin-18

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SB-485232

Papers overview

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Highly Cited
2009
Highly Cited
2009
Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice.
Although Francisella tularensis subsp. tularensis is known to cause extensive tissue necrosis, the pathogenesis of tissue injury… Expand
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Highly Cited
2009
Highly Cited
2009
Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens.
Assessment of allergenic potential of chemicals is performed using animal models, such as the murine local lymph node assay… Expand
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Highly Cited
2008
Highly Cited
2008
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Aluminium adjuvants, typically referred to as ‘alum’, are the most commonly used adjuvants in human and animal vaccines worldwide… Expand
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Highly Cited
2008
Highly Cited
2008
Interleukin-18 production and pulmonary function in COPD.
Interleukin (IL)-18 production and pulmonary function were evaluated in patients with chronic obstructive pulmonary disease (COPD… Expand
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Review
2007
Review
2007
The dual effects of interleukin-18 in tumor progression.
Interleukin-18 (IL-18) was discovered as an interferon-gamma-inducing factor and had a critical role in inflammatory and immune… Expand
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Highly Cited
2006
Highly Cited
2006
Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways.
Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid… Expand
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Highly Cited
2005
Highly Cited
2005
Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance.
OBJECTIVE Activated innate immunity is thought to be involved in the pathogenesis of metabolic syndrome and type 2 diabetes… Expand
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Highly Cited
2001
Highly Cited
2001
The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro
The effects of the pro-inflammatory cytokine interleukin-18 (IL-18) were investigated on both normal and isolated N-methyl-D… Expand
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Highly Cited
2000
Highly Cited
2000
Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta.
Interleukin-18 (IL-18) is not only a co-stimulus for the induction of interferon-gamma but also has direct proinflammatory… Expand
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Highly Cited
1996
Highly Cited
1996
Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production.
The novel cytokine interferon-gamma-inducing factor (IGIF) augments natural killer (NK) cell activity in cultures of human… Expand
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