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Cyclooxygenase‐independent actions of cyclooxygenase inhibitors
- I. Tegeder, J. Pfeilschifter, G. Geisslinger
- Biology, MedicineFASEB journal : official publication of the…
- 1 October 2001
Differences in cyclooxygenase‐independent mechanisms may have consequences for the specific use of these drugs in individual patients because additional effects may either enhance the efficacy or reduce the toxicity of the respective compounds.
Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair.
- C. Wetzler, H. Kämpfer, B. Stallmeyer, J. Pfeilschifter, S. Frank
- Biology, MedicineThe Journal of investigative dermatology
- 1 August 2000
The data provide evidence that late infiltration of neutrophils and macrophages into wounds in db/db mice was associated with a simultaneous downregulation of mRNA for receptors specific for macrophage inflammatory protein-2 andmacrophage chemoattractant protein-1 in these animals.
Physiology and pathophysiology of sphingolipid metabolism and signaling.
Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21
Decorin was an early response gene evoked by septic inflammation, and protein concentrations of decorin were increased in the plasma of septic patients and mice, and this pathway operates in both pathogen-mediated and sterile inflammation.
Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors*
The results provide evidence for direct activation of the NLRP3 inflammasome by biglycan and describe a fundamental paradigm of how tissue stress or injury is monitored by innate immune receptors detecting the release of the extracellular matrix components and turning such a signal into a robust inflammatory response.
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR.
SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis
It is found that the enzyme sphingosine kinase 1 (SphK1) is up-regulated in stimulated human phagocytes and in peritoneal phagocyte of patients with severe sepsis and suggest that inhibition of SphK1 is a potential therapy for septic shock.
Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells
- T. Djordjevic, R. Belaiba, S. Bonello, J. Pfeilschifter, J. Hess, A. Görlach
- Biology, MedicineArteriosclerosis, thrombosis, and vascular…
- 1 March 2005
Findings suggest that hU-II may play a novel role in pulmonary hypertension by promoting remodeling processes via activation of NADPH oxidases and increased proliferation in PASMCs.
Inducible NO synthase: role in cellular signalling.
The discovery of endothelium-derived relaxing factor and its identification as nitric oxide (NO) was one of the most exciting discoveries of biomedical research in the 1980s. Besides its potent…
Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA
Using RNA interference technology and actinomycin D experiments, it is demonstrated that in human mesangial cells (hMC) the amplification of cytokine-induced COX-2 by angiotensin II (AngII) occurs via a HuR-mediated increase of mRNA stability.