N. Karin

Publications93
h-index41
Citations6,922
Highly Influential Citations238
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • G. Wildbaum
  • 54 Publications • 3,028 Citations
  • L. Steinman
  • 746 Publications • 55,468 Citations
  • J. Casanova
  • 1,051 Publications • 81,865 Citations
  • A. Luster
  • 459 Publications • 57,405 Citations
  • Publications
  • Influence
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.
TLDR
In vitro adhesion assay on tissue sections found that lymphocytes and monocytes bound selectively to inflamed EAE brain vessels, and therapies designed to interfere with alpha 4 beta 1 integrin may be useful in treating inflammatory diseases of the central nervous system, such as multiple sclerosis.
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
Whole-exome sequencing reveals activating STAT1 mutations in some patients with autosomal dominant chronic mucocutaneous candidiasis disease.
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin
TLDR
In vitro adhesion assay on tissue sections found that lymphocytes and monocytes bound selectively to inflamed EAE brain vessels, and therapies designed to interfere with α4βl integrin may be useful in treating inflammatory diseases of the central nervous system, such as multiple sclerosis.
CCR8+FOXp3+ Treg cells as master drivers of immune regulation
TLDR
The pivotal role of CCR8+ Treg cells in restraining immunity is demonstrated and the potential clinical implications of this discovery are highlighted.
Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells.
TLDR
The anti-ergotypic response thus combines with the previously shown anti-idiotypic T cell response to regulate autoimmunity.
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.
TLDR
Administration of CXCL11-Ig during the first episode of relapsing EAE in SJL/J mice not only led to rapid remission, but also prevented subsequent relapse, suggesting that CxCL11 has the potential to restrain inflammatory autoimmunity.
Long-lasting protective immunity to experimental autoimmune encephalomyelitis following vaccination with naked DNA encoding C-C chemokines.
TLDR
Modulation of EAE with C-C chemokine DNA vaccines is dependent on targeting chemokines that are highly transcribed at the site of inflammation at the onset of disease.
The multiple faces of CXCL12 (SDF‐1α) in the regulation of immunity during health and disease
  • N. Karin
  • Biology, Medicine
    Journal of leukocyte biology
  • 1 September 2010
TLDR
It is shown recently that CXCL12 increases immunological tolerance in autoimmune diseases by polarizing Tregs and by doing so, restrains the progression of these diseases.
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
TLDR
It is shown that when clone L10C1 is tolerized in vivo with an analogue of p87–99, established paralysis is reversed, inflammatory infiltrates regress, and the heterogeneous T-cell infiltrate disappears from the brain, with only the T-cells that incited disease remaining in the original lesions.
CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells
TLDR
The results not only demonstrate, for the first time, that a chemokine functions as a regulatory mediator, but also suggest a novel way for treating multiple sclerosis and possibly other inflammatory autoimmune diseases.
...
1
2
3
4
5
...