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indimitecan

Known as: 5H-(1,3)Dioxolo(4',5':5,6)indeno(1,2-c)isoquinoline-5,12(6H)-dione, 6-(3-(1H-imidazol-1-xyl)propyl)-2,3-dimethoxy-, LMP776 
National Institutes of Health

Papers overview

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2020
2020
Triple-negative breast cancer xenografts with BRCAness, high expression of SLFN11, and RB1 loss are highly sensitive to… Expand
Review
2019
Review
2019
Irinotecan and topotecan have been widely used as anticancer drugs for the past 20 years. Because of their selectivity as… Expand
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2019
2019
Purpose: Irinotecan and topotecan are used to treat a variety of different cancers. However, they have limitations, including… Expand
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2018
2018
Purpose: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and… Expand
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2018
2018
To relax DNA supercoiling, topoisomerase I (TOP1) induces DNA cleavage complexes (TOP1cc). These TOP1cc can be trapped by… Expand
2017
2017
To relax DNA supercoiling during transcription and replication, topoisomerase I (Top1) induces transient DNA cleavage complexes… Expand
2016
2016
An HPLC method for the assay of a DNA topoisomerase inhibitor, LMP776 (NSC 725776), has been developed and validated. The stress… Expand
2014
2014
Carbohydrate moieties were strategically transported from the indolocarbazole topoisomerase I (Top1) inhibitor class to the… Expand
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2012
2012
Hydroxylated analogues of the anticancer topoisomerase I (Top1) inhibitors indotecan (LMP400) and indimitecan (LMP776) have been… Expand
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Highly Cited
2009
Highly Cited
2009
Because camptothecins are effective against previously resistant tumors and are the only class of topoisomerase I (Top1… Expand
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