Skip to search formSkip to main contentSkip to account menu

indimitecan

Known as: 5H-(1,3)Dioxolo(4',5':5,6)indeno(1,2-c)isoquinoline-5,12(6H)-dione, 6-(3-(1H-imidazol-1-xyl)propyl)-2,3-dimethoxy-, LMP776 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzodioxolesIsoquinolines

Narrower (1)

Topoisomerase I Inhibitor LMP776

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 4855: Indotecan (LMP400), Imidotecan (LMP776) and LMP744: A new class of non-camptothecin TOP1 inhibitors selective for cancer cells with homologous recombination deficiencies and high…
To relax DNA supercoiling, topoisomerase I (TOP1) induces DNA cleavage complexes (TOP1cc). These TOP1cc can be trapped by… 
2018
2018
Abstract 2662: Indenoisoquinoline topoisomerase I inhibitors target the DNA G-quadruplex formed in the c-Myc promoter and cause MYC downregulation
The inhibition of DNA topoisomerase I (Top1) has proven to be a successful approach toward the design of anticancer agents… 
2017
2017
Abstract 2794: Indotecan (LMP400), imidotecan (LMP776) and LMP744: A new class of non-camptothecin Top1 inhibitors selective for homologous recombination deficient (HRD) cells
To relax DNA supercoiling during transcription and replication, topoisomerase I (Top1) induces transient DNA cleavage complexes… 
2016
2016
HPLC method development, validation, and impurity characterization of a potent antitumor indenoisoquinoline, LMP776 (NSC 725776).
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)