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Triple-negative breast cancer xenografts with BRCAness, high expression of SLFN11, and RB1 loss are highly sensitive to… Expand Irinotecan and topotecan have been widely used as anticancer drugs for the past 20 years. Because of their selectivity as… Expand Purpose: Irinotecan and topotecan are used to treat a variety of different cancers. However, they have limitations, including… Expand Purpose: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and… Expand To relax DNA supercoiling, topoisomerase I (TOP1) induces DNA cleavage complexes (TOP1cc). These TOP1cc can be trapped by… Expand To relax DNA supercoiling during transcription and replication, topoisomerase I (Top1) induces transient DNA cleavage complexes… Expand An HPLC method for the assay of a DNA topoisomerase inhibitor, LMP776 (NSC 725776), has been developed and validated. The stress… Expand Carbohydrate moieties were strategically transported from the indolocarbazole topoisomerase I (Top1) inhibitor class to the… Expand Hydroxylated analogues of the anticancer topoisomerase I (Top1) inhibitors indotecan (LMP400) and indimitecan (LMP776) have been… Expand Because camptothecins are effective against previously resistant tumors and are the only class of topoisomerase I (Top1… Expand