FAQ

indacrinone

Known as: 6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxyacetic acid, indanone 
An orally active, indanone-based loop diuretic that consists of a racemic mixture. The (-) enantiomer is natriuretic, and the (+) enantiomer is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1947-2018
051019472017

Related topics

Related topics

8 relations

Broader (4)

DiureticsIndanonesIndansUricosuric Agents

Narrower (4)

MK 196MK 286indanone, (R)-isomerindanone, (S)-isomer

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
indacrinone
Diuretics
Uricosuric Agents
Indanones
MK 196
Indans

Papers overview

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2011
2011
Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells.
Vimang is a standardized extract derived from Mango bark (Mangifera Indica L.), commonly used as anti-inflammatory phytomedicine… (More)
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Highly Cited
2007
Highly Cited
2007
A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.
Recent clinical studies reveal that selective agonists of group II metabotropic glutamate (mGlu) receptors have robust efficacy… (More)
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2007
2007
A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors.
Group II metabotropic glutamate receptors (mGluRs), mGluR2 and mGluR3, play a number of important roles in mammalian brain and… (More)
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Highly Cited
2006
Highly Cited
2006
Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
Previous studies indicate that agonists of the group II metabotropic glutamate receptors (mGluRs), mGluR2 and mGluR3, may provide… (More)
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2005
2005
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
A new series of donepezil-tacrine hybrid related derivatives have been synthesised as dual acetylcholinesterase inhibitors that… (More)
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2005
2005
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
We have identified and synthesized a series of phenyl-tetrazolyl and 4-thiopyridyl indanones as allosteric potentiators of the… (More)
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2000
2000
Tubulin/microtubules: still a promising target for new chemotherapeutic agents.
Most investigators would agree that the ideal chemotherapeutic agent should be 1) directed at a validated target; 2) potent… (More)
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1997
1997
New metabolites in the degradation of fluorene by Arthrobacter sp. strain F101.
Identification of new metabolites and demonstration of key enzyme activities support and extend the pathways previously reported… (More)
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1996
1996
The rationale for E2020 as a potent acetylcholinesterase inhibitor.
The phase III drug-candidate, E2020, developed for treatment of Alzheimer's disease, and possibly other demenitas, and its… (More)
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1995
1995
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Following the discovery of a new series of anti-acetylcholinesterase (anti-AChE) inhibitors such as 1-benzyl-4-[2-(N-benzoylamino… (More)
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