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indacrinone
Known as:
6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxyacetic acid
, indanone
An orally active, indanone-based loop diuretic that consists of a racemic mixture. The (-) enantiomer is natriuretic, and the (+) enantiomer is…
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National Institutes of Health
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Related topics
Related topics
8 relations
Broader (4)
Diuretics
Indanones
Indans
Uricosuric Agents
Narrower (4)
MK 196
MK 286
indanone, (S)-isomer
indanone, sodium salt
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold.
Xiang Li
,
Lei Yang
,
+8 authors
Bo Han
Chemical Communications
2013
Corpus ID: 205840611
A novel multicatalytic MBH-Michael tandem reaction has been developed for the asymmetric assembly of ninhydrin, nitroolefins and…
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2009
2009
BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide.
Jing Zhang
,
Difeng Zhu
,
+6 authors
Qiaojun He
European Journal of Pharmacology
2009
Corpus ID: 21921996
2009
2009
Binding of indanocine to the colchicine site on tubulin promotes fluorescence, and its binding parameters resemble those of the colchicine analogue AC.
Lalita Das
,
Suvroma Gupta
,
D. Dasgupta
,
Asim Poddar
,
Mark E. Janik
,
B. Bhattacharyya
Biochemistry
2009
Corpus ID: 22556137
Indanocine, a synthetic indanone, has shown potential antiproliferative activity against several tumor types. It is different…
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2007
2007
Synthesis of indanones via solid-supported [2+2+2] cyclotrimerization.
R. Senaiar
,
J. Teske
,
D. Young
,
A. Deiters
Journal of Organic Chemistry
2007
Corpus ID: 38691874
A new facile approach toward natural and unnatural indanones has been developed, featuring a solid-supported [2+2+2…
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2005
2005
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
A. Pinkerton
,
R. Cube
,
+8 authors
J. Vernier
Bioorganic & Medicinal Chemistry Letters
2005
Corpus ID: 655546
2004
2004
Investigation into the mast cell stabilizing activity of nature‐identical and synthetic indanones
N. Frankish
,
R. Farrell
,
H. Sheridan
The Journal of pharmacy and pharmacology
2004
Corpus ID: 22561444
As part of an ongoing search for novel molecules with therapeutic potential we examined the mediator release inhibition activity…
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2001
2001
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes.
P. Finke
,
L. C. Meurer
,
+9 authors
J. DeMartino
Bioorganic & Medicinal Chemistry Letters
2001
Corpus ID: 7107418
1994
1994
Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program
Y. Pang
,
A. Kozikowski
J. Comput. Aided Mol. Des.
1994
Corpus ID: 206768774
SummaryIn the preceding paper we reported on a docking study with the SYSDOC program for predicting the binding sites of…
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1988
1988
Metal mediated routes to 5-membered rings
L. S. Liebeskind
,
R. Chidambaram
,
D. Mitchell
,
B. S. Foster
1988
Corpus ID: 96811343
Abstract
Highly Cited
1977
Highly Cited
1977
A new total synthesis of dl-pumiliotoxin-C via an indanone.
W. Oppolzer
,
Charles Fehr
,
J. Warneke
Helvetica Chimica Acta
1977
Corpus ID: 30118874
dl-Pumiliotoxin-C (4) was synthesized in a practical manner from trans-4-hexenal (9). The key step 14 15 (Scheme 3) involves an…
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