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indacrinone

Known as: 6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxyacetic acid, indanone 
An orally active, indanone-based loop diuretic that consists of a racemic mixture. The (-) enantiomer is natriuretic, and the (+) enantiomer is… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (4)

DiureticsIndanonesIndansUricosuric Agents

Narrower (4)

MK 196MK 286indanone, (S)-isomerindanone, sodium salt

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold.
A novel multicatalytic MBH-Michael tandem reaction has been developed for the asymmetric assembly of ninhydrin, nitroolefins and… 
Highly Cited
2009
Highly Cited
2009
Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture.
2009
2009
BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide.
2008
2008
Bioactive diterpenes and other constituents of Croton steenkampianus.
A new indanone derivative (1) and two new diterpenoids (2 and 3), together with three known flavonoids, have been isolated from… 
Highly Cited
2006
Highly Cited
2006
Synthesis of indenyl ethers by gold(I)-catalyzed intramolecular carboalkoxylation of alkynes.
The gold(I)-catalyzed carboalkoxylation of alkynes to form indanone derivatives from readily available ortho-acetylenic benzylic… 
2005
2005
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
2004
2004
Investigation into the mast cell stabilizing activity of nature‐identical and synthetic indanones
As part of an ongoing search for novel molecules with therapeutic potential we examined the mediator release inhibition activity… 
2001
2001
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes.
1988
1988
Metal mediated routes to 5-membered rings
Abstract 
Highly Cited
1977
Highly Cited
1977
A new total synthesis of dl-pumiliotoxin-C via an indanone.
dl-Pumiliotoxin-C (4) was synthesized in a practical manner from trans-4-hexenal (9). The key step 14 15 (Scheme 3) involves an… 
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