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MK 196

Known as: MK-196 
National Institutes of Health

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indacrinone

Papers overview

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1998
1998
Cell volume regulation in proximal renal tubules from trout (Salmo trutta).
Regulatory volume decrease (RVD) following hypo-osmotic stimulation was studied using videometric methods in isolated proximal… 
1993
1993
cAMP-activated apical membrane chloride channels in Necturus gallbladder epithelium. Conductance, selectivity, and block
Elevation of intracellular cAMP levels in Necturus gallbladder epithelium (NGB) induces an apical membrane Cl- conductance (GaCl… 
1987
1987
Ototoxicity of indacrinone is stereospecific
1986
1986
Indacrinone (MK-196)--a specific inhibitor of the voltage-dependent Cl- permeability in toad skin.
The effect of indacrinone (MK-196) on Cl- transport through toad (Bufo bufo) skin epithelium was studied by the voltage clamping… 
1985
1985
Opposite effects of indacrinone (MK-196) on sodium and chloride conductance of amphibian skin
Indacrinone, a drug chemically related to ethacrynic acid, usually stimulated reversibly short circuit current and sodium influx… 
1982
1982
Free-flow micropuncture study of renal urate transport in the Munich-Wistar rat.
In order to determine the nephron sites of urate reabsorption, the fractional rates of delivery of urate to specific segments of… 
1981
1981
Chloride transport inhibition by piretanide and MK-196 in bullfrog corneal epithelium.
Two new diuretic agents, piretanide and MK-196, inhibited short-circuit current (SCC) across the isolated frog corneal epithelium… 
1981
1981
(Acylaryloxy)acetic acid diuretics. 4. Indeno[5,4-b]furan-2-carboxylic acids.
Investigation of the chemistry of the potent new uricosuric diuretic indacrinone (MK-196) led to a class of novel annulated… 
1979
1979
A double-blind comparison of a novel indanone diuretic (MK-196) with hydrochlorothiazide in the treatment of essential hypertension.
1 The antihypertensive effect and tolerability of MK-196 (10 mg and 15 mg daily) was compared to hydrochlorothiazide (HCT; 50 mg… 
1979
1979
Uricosuric response to increasing doses of the indanone diuretic MK-196 in healthy volunteers.
Doses of 20, 40, 60 and 80 mg of the indanone diuretic MK-196 and 40 mg of frusemide were administered in random order to 5… 
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