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hydroxymaprotilin, (+R)-isomer

Known as: LEVOPROTILINE 
National Institutes of Health

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Broader (2)

Maprotilinehydroxymaprotilin

Papers overview

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2005
2005
Single treatments with the antidepressant oxaprotiline and its (+) and (−) enantiomers increase behavioural responses to dopaminergic stimulation in the rat
The effects of single doses of oxaprotiline and its (+)- and (−)-enantiomers (CGP 12 104 A and CGP 12 103 A, provisional generic… 
2004
2004
Oxaprotiline: enantioselective noradrenaline uptake inhibition indicated by intravenous amine pressor tests but not α2-adrenoceptor binding to intact platelets in man
SummaryThe optically active isomers of the racemic tetracyclic antidepressant oxaprotiline, R (−) oxaprotiline CGP 12 103 A… 
1993
1993
Predicting Therapeutic Results with Levoprotiline and Maprotiline in Major Depression: The Role of the Outcome Criteria
We describe a double-blind study involving 58 in-patients with major depression (DSM-III). After one week on placebo, the… 
1992
1992
Changes in the rat brain 5-HT1A and 5-HT2 receptors after chronic administration of levoprotiline, (+)-oxaprotiline and other antidepressant drugs.
The effects of levoprotiline (LEV), a (-)-enantiomer of oxaprotiline (OXA) and a clinically effective antidepressant, on the… 
1992
1992
Pharmacological profile of the new antidepressant levoprotiline.
The pharmacological properties of a new antidepressant, levoprotiline ((-)-R-a-[(methylamino)methyl]-9,10-ethanoanthracene-9(10H… 
1991
1991
Pharmaco-EEG Profile of Levoprotiline:
The present paper forms the second part of a critical evaluation of the use of pharmaco-EEG as an instrument for assessing the… 
1991
1991
Acute effects of antidepressant drugs on long-term potentiation (LTP) in rat hippocampal slices
SummaryThe actions of three clinically effective antidepressant drugs with different pharmacological profiles were investigated… 
1991
1991
Determination of the antidepressant levoprotiline and its N-desmethyl metabolite in biological fluids by gas chromatography/mass spectrometry.
A specific and sensitive gas chromatographic/mass spectrometric method was developed and validated for the determination of the… 
1990
1990
Levoprotiline: Clinical Therapeutic Efficacy and Tolerability
The development of antidepressants and of theories as to the causes of depression have taken a parallel course and have… 
1989
1989
Rapid changes in functional responsiveness of the 5-HT system after single-dose and multiple-dose treatment with antidepressants: effects of maprotiline and oxaprotiline and its enantiomers
Functional responsiveness to 5-HTP (L-5-hydroxytryptophan) and quipazine 24 h after one single dose and 24 h and 72 h after… 
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