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Histamine in the nervous system.
Mutual interactions with other transmitter systems form a network that links basic homeostatic and higher brain functions, including sleep-wake regulation, circadian and feeding rhythms, immunity, learning, and memory in health and disease. Expand
The physiology of brain histamine
The central histamine system is involved in many central nervous system functions: arousal; anxiety; activation of the sympathetic nervous system; the stress-related release of hormones from the pituitary and of central aminergic neurotransmitters; antinociception; water retention and suppression of eating. Expand
The role of histamine and the tuberomamillary nucleus in the nervous system
The localization, biochemistry and physiological functions of the components of the histaminergic system, a phylogenetically old group of neurons that project to most of the central nervous system, are discussed. Expand
International Union of Pharmacology. XIII. Classification of histamine receptors.
The classification of histamine receptors has to date been based on rigorous classical pharmacological analysis, and as yet, the classification of the three histamines receptors that have been defined by this process have not been added to because of lack of evidence. Expand
Orexin/Hypocretin Excites the Histaminergic Neurons of the Tuberomammillary Nucleus
A functional connection between the two populations of hypothalamic neurons is suggested and that they may cooperate in the regulation of rapid-eye-movement sleep and feeding. Expand
Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins
Dysfunction of the orexin modulation of VTA neurons may be important in triggering attacks of cataplexy in narcolepsy, in which the Orexin system is disrupted. Expand
Comparison of the actions of adenosine at pre‐ and postsynaptic receptors in the rat hippocampus in vitro.
DPCPX increased the rate of spontaneous bursting, consistent with a tonic activation of adenosine receptors during hyperactivity, and led to the development of prolonged ictal‐like bursts, suggesting that the endogenous release ofadenosine may contribute to the termination of epileptic bursts. Expand
Convergent Excitation of Dorsal Raphe Serotonin Neurons by Multiple Arousal Systems (Orexin/Hypocretin, Histamine and Noradrenaline)
Agonists of three arousal-related systems impinging on the dorsal raphe caused an inward current and increase in current noise in whole-cell patch-clamp recordings from these neurons in brain slices, suggesting that all three systems act via common effector mechanisms. Expand
Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat
Orexin A (10-300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 microM) and was associated with anExpand
Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmission
It is reported here that spontaneous firing of all the neurones recorded in the slice increased, consistent with the known effects of Ca2+ on membrane properties and synaptic transmission6–10, but the synchronous ‘field bursts’, and presumably their underlying mechanisms, were restricted to the population of pyramidal neurones in the hippocampal CA1 region. Expand