• Publications
  • Influence
Mammalian p53 can function as a transcription factor in yeast
TLDR
It is shown here that mammalian p53 expressed in S. cerevisiae is able to activate transcription of a reporter gene placed under the control of a CYC1 hybrid promoter containing the 33 base pair p53-binding sequence. Expand
Quasi-normal cornified cell envelopes in loricrin knockout mice imply the existence of a loricrin backup system.
TLDR
Observations imply that the epidermis and forestomach epithelium of these mice have elevated levels of the small proline-rich proteins, and cell envelopes of both kinds contain other protein(s) that, like loricrin, are rich in glycine and serine. Expand
[Non-oral administration of progesterone: experiences and possibilities of the transvaginal route].
TLDR
This modality permits application of estradiol and progesterone in a physiological manner by a non oral route and appears particularly interesting in patients at cardiovascular risk. Expand
Mammalian p53 can function as a transcription factor in yeast.
TLDR
It is shown here that mammalian p53 expressed in S. cerevisiae is able to activate transcription of a reporter gene placed under the control of a CYC1 hybrid promoter containing the 33 base pair p53-binding sequence. Expand
Pharmaco-EEG profile of levoprotiline: second example to discuss the predictive value of pharmaco-electroencephalography in early human pharmacological evaluations of psychoactive drugs.
This publication forms the third part of a critical evaluation of pharmaco-EEG applications as an instrument for assessing the profile of action of psychoactive drugs based on the trial results ofExpand
Predictive value of pharmaco-electroencephalography in early human-pharmacological evaluations of psychoactive drugs. First example: savoxepine.
TLDR
The results favour the hypothesis that pharmaco-EEG has a value in predicting the quality of action of a new drug in man and favour the complementary use of pharmaco -EEG in human pharmacology testing in order to objectively assess central effects of drugs and rationally estimate the doses for therapeutic trials. Expand
Pharmaco-EEG profile of levoprotiline: second example to discuss the predictive value of pharmaco-electroencephalography in early human pharmacological evaluations of psychoactive drugs.
TLDR
This chapter illustrates the relevance of pharmaco-EEG in the assessment of psychoactive drugs by reference to the test substance levoprotiline and the assumption that this drug was devoid of an antidepressive action was disproved. Expand
The long-term tolerability of bencyclane ('Fludilat') in patients with peripheral occlusive disease: a 48-week prospective double-blind controlled study versus placebo.
TLDR
The parameters used to assess the efficacy, i.e. the pain-free walking distance estimated by the patients and the physician's global judgment based on Ratschow's test, the palpability of the pedal pulse, the walking range and the patients' subjective statements about the incidence of chill, formication, and pain in the legs, showed a constant and statistically significant superiority of bencyclane over placebo. Expand
Pharmaco-EEG profile of maroxepine: third example to discuss the predictive value of pharmaco-electroencephalography in early human pharmacological evaluations of psychoactive drugs.
TLDR
The pharmaco-EEG effects of maroxepine were investigated in a randomised, double-blind study in 15 young healthy male subjects and compared with those of placebo and the reference substances, chlorpromazine and imipramine, showing that maroxEPine has a potent central nervous action and a strong sedative potential. Expand
...
1
2
...