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homocitrate synthase activity
Known as:
acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity
, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)
, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity
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Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [EC:2.3.3.14, RHEA:12932]
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Disruption of Homocitrate Synthase Genes in Candida albicans Affects Growth But Not Virulence
K. Kur
,
I. Gabriel
,
J. Morschhäuser
,
F. Barchiesi
,
E. Spreghini
,
S. Milewski
Mycopathologia
2010
Corpus ID: 9844137
Two genes, LYS21 and LYS22, encoding isoforms of homocitrate synthase, an enzyme catalysing the first committed step in the…
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2005
2005
Grafías coa-, quoa-, goa- en documentos medievales guipuzcoanos (Arrasate-Mondragón)
Sara Gómez Seibane
2005
Corpus ID: 126681899
2001
2001
Subcellular localization of the homocitrate synthase in Penicillium chrysogenum
O. Bañuelos
,
J. Casqueiro
,
S. Steidl
,
S. Gutiérrez
,
A. Brakhage
,
J. Martín
Zeitschrift für Induktive Abstammungs- und…
2001
Corpus ID: 28926859
Abstract. There are conflicting reports regarding the cellular localization in Saccharomyces cerevisiae and filamentous fungi of…
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2000
2000
Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, α-aminoadipic acid pool and penicillin production
O. Bañuelos
,
J. Casqueiro
,
S. Gutiérrez
,
J. Martín
Applied Microbiology and Biotechnology
2000
Corpus ID: 9554489
Abstract Homocitrate synthase activity (encoded by the lys1 gene) catalyzes the first step of the lysine and penicillin pathway…
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1990
1990
Homocitrate synthase from Penicillium chrysogenum. Localization, purification of the cytosolic isoenzyme, and sensitivity to lysine.
W. Jaklitsch
,
W. Jaklitsch
,
C. Kubicek
Biochemical Journal
1990
Corpus ID: 40475775
Subcellular fractionation of cell-free extracts obtained by nitrogen cavitation showed that Penicillium chrysogenum Q176 contains…
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Highly Cited
1980
Highly Cited
1980
Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum
J. Luengo
,
G. Revilla
,
M. J. Lopez
,
J. R. Villanueva
,
J. Martín
Journal of Bacteriology
1980
Corpus ID: 20857601
Homocitrate synthase in the first enzyme of the lysine biosynthetic pathway. It is feedback regulated by L-lysine. Lysine…
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1979
1979
Evidence for mutations in the structural gene for homocitrate synthase in Saccharomycopsis lipolytica
C. Gaillardin
,
H. Heslot
Molecular and General Genetics MGG
1979
Corpus ID: 13620382
SummaryEight strains devoid of homocitrate synthase activity were found among lysine requiring mutants of the yeast…
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1976
1976
A kinetic study of homocitrate synthetase activity in the yeast Saccharomycopsis lipolytica.
C. Gaillardin
,
L. Poirier
,
H. Heslot
Biochimica et Biophysica Acta
1976
Corpus ID: 31084194
1976
1976
Biosynthesis of lysine in Saccharomyces cervisiae: properties and spectrophotometric determination of homocitrate synthase activity.
G. Gray
,
J. K. Bhattacharjee
Canadian Journal of Microbiology (print)
1976
Corpus ID: 29140004
A rapid assay is described for homocitrate synthase (EC 4.1.3.21) of the lysine biosynthetic pathway of Saccharomyces cerevisiae…
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1974
1974
Insensitivity of homocitrate synthase in extracts of Penicillium chyrosogenum to feedback inhibition by lysine.
P. Masurekar
,
A. Demain
Applied microbiology
1974
Corpus ID: 29020683
We previously reported that lysine inhibits in vivo homocitrate synthesis in the lysine bradytroph, Penicillium chrysogenum L(1…
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