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homocitrate synthase activity

Known as: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity 
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [EC:2.3.3.14, RHEA:12932]
National Institutes of Health

Papers overview

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2010
2010
Disruption of Homocitrate Synthase Genes in Candida albicans Affects Growth But Not Virulence
Two genes, LYS21 and LYS22, encoding isoforms of homocitrate synthase, an enzyme catalysing the first committed step in the… 
2005
2005
Grafías coa-, quoa-, goa- en documentos medievales guipuzcoanos (Arrasate-Mondragón)
2001
2001
Subcellular localization of the homocitrate synthase in Penicillium chrysogenum
Abstract. There are conflicting reports regarding the cellular localization in Saccharomyces cerevisiae and filamentous fungi of… 
2000
2000
Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, α-aminoadipic acid pool and penicillin production
Abstract Homocitrate synthase activity (encoded by the lys1 gene) catalyzes the first step of the lysine and penicillin pathway… 
1990
1990
Homocitrate synthase from Penicillium chrysogenum. Localization, purification of the cytosolic isoenzyme, and sensitivity to lysine.
Subcellular fractionation of cell-free extracts obtained by nitrogen cavitation showed that Penicillium chrysogenum Q176 contains… 
Highly Cited
1980
Highly Cited
1980
Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum
Homocitrate synthase in the first enzyme of the lysine biosynthetic pathway. It is feedback regulated by L-lysine. Lysine… 
1979
1979
Evidence for mutations in the structural gene for homocitrate synthase in Saccharomycopsis lipolytica
SummaryEight strains devoid of homocitrate synthase activity were found among lysine requiring mutants of the yeast… 
1976
1976
A kinetic study of homocitrate synthetase activity in the yeast Saccharomycopsis lipolytica.
1976
1976
Biosynthesis of lysine in Saccharomyces cervisiae: properties and spectrophotometric determination of homocitrate synthase activity.
A rapid assay is described for homocitrate synthase (EC 4.1.3.21) of the lysine biosynthetic pathway of Saccharomyces cerevisiae… 
1974
1974
Insensitivity of homocitrate synthase in extracts of Penicillium chyrosogenum to feedback inhibition by lysine.
We previously reported that lysine inhibits in vivo homocitrate synthesis in the lysine bradytroph, Penicillium chrysogenum L(1… 
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