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homocitrate synthase activity

Known as: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity 
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [EC:2.3.3.14, RHEA:12932]
National Institutes of Health

Papers overview

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2017
2017
Nitrogenase is known for its remarkable ability to catalyze the reduction of N2 to NH3, and C1 substrates to short-chain… Expand
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2011
2011
The FeMoco of Mo-nitrogenase provides the active site for substrate reduction. Previously, a FeMoco precursor was captured on… Expand
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2008
2008
Nature has exploited the structural and electronic plasticity of small inorganic structures called [Fe-S] clusters (Fig. 1) in at… Expand
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2001
2001
Abstract. There are conflicting reports regarding the cellular localization in Saccharomyces cerevisiae and filamentous fungi of… Expand
2000
2000
Abstract Homocitrate synthase activity (encoded by the lys1 gene) catalyzes the first step of the lysine and penicillin pathway… Expand
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Highly Cited
1999
Highly Cited
1999
Expression of the structural genes for lysine biosynthesis responds to an induction mechanism mediated by the transcriptional… Expand
Highly Cited
1980
Highly Cited
1980
Homocitrate synthase in the first enzyme of the lysine biosynthetic pathway. It is feedback regulated by L-lysine. Lysine… Expand
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1976
1976
1. A rapid method for estimating the activity of the first enzyme of lysine biosynthesis in yeasts (acetyl-coenzyme A: 2… Expand
1976
1976
A rapid assay is described for homocitrate synthase (EC 4.1.3.21) of the lysine biosynthetic pathway of Saccharomyces cerevisiae… Expand