FAQ

homocitrate synthase activity

Known as: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity 
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [EC:2.3.3.14, RHEA:12932]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2010
01219742010

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Identification and characterization of a re-citrate synthase in Dehalococcoides strain CBDB1.
The genome annotations of all sequenced Dehalococcoides strains lack a citrate synthase, although physiological experiments have… (More)
Is this relevant?
2010
2010
Disruption of Homocitrate Synthase Genes in Candida albicans Affects Growth But Not Virulence
Two genes, LYS21 and LYS22, encoding isoforms of homocitrate synthase, an enzyme catalysing the first committed step in the… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
Is this relevant?
2007
2007
Effects of disruption of homocitrate synthase genes on Nostoc sp. strain PCC 7120 photobiological hydrogen production and nitrogenase.
In the case of nitrogenase-based photobiological hydrogen production systems of cyanobacteria, the inactivation of uptake… (More)
Is this relevant?
2001
2001
Subcellular localization of the homocitrate synthase in Penicillium chrysogenum
There are conflicting reports regarding the cellular localization in Saccharomyces cerevisiae and filamentous fungi of… (More)
Is this relevant?
2000
2000
Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, α-aminoadipic acid pool and penicillin production
 Homocitrate synthase activity (encoded by the lys1 gene) catalyzes the first step of the lysine and penicillin pathway and is… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1999
1999
In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p.
Expression of the structural genes for lysine biosynthesis responds to an induction mechanism mediated by the transcriptional… (More)
Is this relevant?
1990
1990
Homocitrate synthase from Penicillium chrysogenum. Localization, purification of the cytosolic isoenzyme, and sensitivity to lysine.
Subcellular fractionation of cell-free extracts obtained by nitrogen cavitation showed that Penicillium chrysogenum Q176 contains… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1980
1980
Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum.
Homocitrate synthase in the first enzyme of the lysine biosynthetic pathway. It is feedback regulated by L-lysine. Lysine… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1976
1976
Biosynthesis of lysine in Saccharomyces cervisiae: properties and spectrophotometric determination of homocitrate synthase activity.
A rapid assay is described for homocitrate synthase (EC 4.1.3.21) of the lysine biosynthetic pathway of Saccharomyces cerevisiae… (More)
Is this relevant?
1974
1974
Insensitivity of homocitrate synthase in extracts of Penicillium chyrosogenum to feedback inhibition by lysine.
We previously reported that lysine inhibits in vivo homocitrate synthesis in the lysine bradytroph, Penicillium chrysogenum L(1… (More)
  • figure 1
  • table 1
  • table 4
  • table 5
  • table 3
Is this relevant?