homocitrate synthase activity

Known as: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity 
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [EC:2.3.3.14, RHEA:12932]
National Institutes of Health

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Topic mentions per year

1974-2010
01219742010

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2011
2011
The genome annotations of all sequenced Dehalococcoides strains lack a citrate synthase, although physiological experiments have… (More)
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2010
2010
Two genes, LYS21 and LYS22, encoding isoforms of homocitrate synthase, an enzyme catalysing the first committed step in the… (More)
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2007
2007
In the case of nitrogenase-based photobiological hydrogen production systems of cyanobacteria, the inactivation of uptake… (More)
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2001
2001
There are conflicting reports regarding the cellular localization in Saccharomyces cerevisiae and filamentous fungi of… (More)
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2000
2000
 Homocitrate synthase activity (encoded by the lys1 gene) catalyzes the first step of the lysine and penicillin pathway and is… (More)
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1999
1999
Expression of the structural genes for lysine biosynthesis responds to an induction mechanism mediated by the transcriptional… (More)
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1990
1990
Subcellular fractionation of cell-free extracts obtained by nitrogen cavitation showed that Penicillium chrysogenum Q176 contains… (More)
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1980
1980
Homocitrate synthase in the first enzyme of the lysine biosynthetic pathway. It is feedback regulated by L-lysine. Lysine… (More)
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1976
1976
A rapid assay is described for homocitrate synthase (EC 4.1.3.21) of the lysine biosynthetic pathway of Saccharomyces cerevisiae… (More)
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1974
1974
We previously reported that lysine inhibits in vivo homocitrate synthesis in the lysine bradytroph, Penicillium chrysogenum L(1… (More)
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