Skip to search formSkip to main contentSkip to account menu

homocitrate synthase activity

Known as: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity 
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [EC:2.3.3.14, RHEA:12932]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Nitrogenase Cofactor Assembly: An Elemental Inventory.
Nitrogenase is known for its remarkable ability to catalyze the reduction of N2 to NH3, and C1 substrates to short-chain… 
2011
2011
Spectroscopic characterization of the isolated iron-molybdenum cofactor (FeMoco) precursor from the protein NifEN.
The FeMoco of Mo-nitrogenase provides the active site for substrate reduction. Previously, a FeMoco precursor was captured on… 
2008
2008
A newly discovered role for iron-sulfur clusters
Nature has exploited the structural and electronic plasticity of small inorganic structures called [Fe-S] clusters (Fig. 1) in at… 
2005
2005
Grafías coa-, quoa-, goa- en documentos medievales guipuzcoanos (Arrasate-Mondragón)
2001
2001
Subcellular localization of the homocitrate synthase in Penicillium chrysogenum
Abstract. There are conflicting reports regarding the cellular localization in Saccharomyces cerevisiae and filamentous fungi of… 
2000
2000
Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, α-aminoadipic acid pool and penicillin production
Abstract Homocitrate synthase activity (encoded by the lys1 gene) catalyzes the first step of the lysine and penicillin pathway… 
Highly Cited
1999
Highly Cited
1999
In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p.
Expression of the structural genes for lysine biosynthesis responds to an induction mechanism mediated by the transcriptional… 
Highly Cited
1980
Highly Cited
1980
Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum
Homocitrate synthase in the first enzyme of the lysine biosynthetic pathway. It is feedback regulated by L-lysine. Lysine… 
1976
1976
A kinetic study of homocitrate synthetase activity in the yeast Saccharomycopsis lipolytica.
1976
1976
Biosynthesis of lysine in Saccharomyces cervisiae: properties and spectrophotometric determination of homocitrate synthase activity.
A rapid assay is described for homocitrate synthase (EC 4.1.3.21) of the lysine biosynthetic pathway of Saccharomyces cerevisiae… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)