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homocitrate synthase activity

Known as: acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity 
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. [EC:2.3.3.14, RHEA:12932]
National Institutes of Health

Papers overview

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2010
2010
Two genes, LYS21 and LYS22, encoding isoforms of homocitrate synthase, an enzyme catalysing the first committed step in the… 
2001
2001
Abstract. There are conflicting reports regarding the cellular localization in Saccharomyces cerevisiae and filamentous fungi of… 
2000
2000
Abstract Homocitrate synthase activity (encoded by the lys1 gene) catalyzes the first step of the lysine and penicillin pathway… 
1990
1990
Subcellular fractionation of cell-free extracts obtained by nitrogen cavitation showed that Penicillium chrysogenum Q176 contains… 
Highly Cited
1980
Highly Cited
1980
Homocitrate synthase in the first enzyme of the lysine biosynthetic pathway. It is feedback regulated by L-lysine. Lysine… 
1979
1979
SummaryEight strains devoid of homocitrate synthase activity were found among lysine requiring mutants of the yeast… 
1976
1976
A rapid assay is described for homocitrate synthase (EC 4.1.3.21) of the lysine biosynthetic pathway of Saccharomyces cerevisiae… 
1974
1974
We previously reported that lysine inhibits in vivo homocitrate synthesis in the lysine bradytroph, Penicillium chrysogenum L(1…