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Regulation of fungal secondary metabolism
TLDR
This Review describes the current understanding of the regulatory elements that modulate the transcription of genes involved in secondary metabolism and discusses how an improved knowledge of these regulatory elements will ultimately lead to a betterUnderstanding of the physiological and ecological functions of these important compounds.
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Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans
TLDR
Results provide evidence of specific interaction among microorganisms belonging to different domains and support the hypothesis that not only diffusible signals but intimate physical interactions contribute to the communication among micro organisms and induction of otherwise silent biosynthesis genes.
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Biosynthesis of fungal melanins and their importance for human pathogenic fungi.
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Interaction of HapX with the CCAAT‐binding complex—a novel mechanism of gene regulation by iron
TLDR
It is demonstrated that iron‐dependent pathways (e.g., heme biosynthesis) are repressed during iron‐depleted conditions by physical interaction of HapX with the CCAAT‐binding core complex (CBC), and that Hap X function is confined to iron‐ Depleted conditions.
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Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA
TLDR
It is established that NET formation occurs in vivo during host defence against A. fumigatus, but it is suggested that it does not play a major role in killing this fungus and may have a fungistatic effect and may prevent further spreading.
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Surface hydrophobin prevents immune recognition of airborne fungal spores
TLDR
It is shown that the surface layer on the dormant conidia masks their recognition by the immune system and hence prevents immune response, and also immunologically silences airborne moulds.
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The akuBKU80 Mutant Deficient for Nonhomologous End Joining Is a Powerful Tool for Analyzing Pathogenicity in Aspergillus fumigatus
TLDR
To increase the frequency of homologous recombination, the KU80 homologue in Aspergillus fumigatus was inactivated and deletion had no influence on pathogenicity in a low-dose murine infection model.
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Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi.
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HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus
TLDR
It is demonstrated that HapX-dependent adaption to conditions of iron starvation is crucial for virulence of A. fumigatus, a opportunistic fungal pathogen facing iron starvation in the host.
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The Aspergillus fumigatus Transcriptional Regulator AfYap1 Represents the Major Regulator for Defense against Reactive Oxygen Intermediates but Is Dispensable for Pathogenicity in an Intranasal Mouse…
TLDR
The hypothesis that ROI such as superoxide anions and peroxides play a direct role in killing of A. fumigatus in an immunocompromised host is challenged.
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