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guanoxan

 
National Institutes of Health

Papers overview

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1994
1994
The effect on insulin release of efaroxan, an alpha 2-adrenoceptor antagonist and a highly potent drug at imidazoline I1… Expand
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1993
1993
The alpha-2 adrenoceptor antagonist idazoxan has been shown to also recognize with high affinity nonadrenoceptor sites (I2… Expand
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1991
1991
A three-dimensional molecular template has been generated for substrates of human debrisoquine 4-hydroxylase cytochrome P450… Expand
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Highly Cited
1990
Highly Cited
1990
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P… Expand
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1989
1989
[3H]Idazoxan is a labelled ligand that is frequently used to study alpha 2-adrenoceptors in the central nervous system. In pig… Expand
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1985
1985
Phenacetin O-deethylase activity was impaired, both in vivo and in vitro, in poor metabolisers of debrisoquine, consistent with… Expand
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1984
1984
Genetic polymorphisms in the oxidative metabolism of debrisoquine, mephenytoin, phenformin, sparteine, and tolbutamide have been… Expand
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1983
1983
In the present study we have investigated the substrate specificity of the form of cytochrome P-450 catalyzing the 4… Expand
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Review
1982
Review
1982
SummaryUntil quite recently, pharmacogenetic polymorphisms in oxidative drug metabolism were considered rare. However during the… Expand
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1978
1978
Eight volunteers previously phenotyped for their ability to hydroxylate debrisoquine (four extensive metabolisers (EM), four poor… Expand
  • table I
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