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guanoxan

 
National Institutes of Health

Papers overview

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Highly Cited
1993
Highly Cited
1993
The alpha-2 adrenoceptor antagonist idazoxan has been shown to also recognize with high affinity nonadrenoceptor sites (I2… Expand
1993
1993
The aim of the present study was to verify whether [3H]idazoxan can be considered as a highly selective ligand for imidazoline… Expand
Highly Cited
1991
Highly Cited
1991
A three-dimensional molecular template has been generated for substrates of human debrisoquine 4-hydroxylase cytochrome P450… Expand
Highly Cited
1990
Highly Cited
1990
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P… Expand
Highly Cited
1989
Highly Cited
1989
[3H]Idazoxan is a labelled ligand that is frequently used to study alpha 2-adrenoceptors in the central nervous system. In pig… Expand
Highly Cited
1984
Highly Cited
1984
Genetic polymorphisms in the oxidative metabolism of debrisoquine, mephenytoin, phenformin, sparteine, and tolbutamide have been… Expand
Highly Cited
1983
Highly Cited
1983
In the present study we have investigated the substrate specificity of the form of cytochrome P-450 catalyzing the 4… Expand
Review
1982
Review
1982
SummaryUntil quite recently, pharmacogenetic polymorphisms in oxidative drug metabolism were considered rare. However during the… Expand
Highly Cited
1978
Highly Cited
1978
Eight volunteers previously phenotyped for their ability to hydroxylate debrisoquine (four extensive metabolisers (EM), four poor… Expand
1967
1967
Guanethidine is a sympatholytic agent (Maxwell et al., 1959), and its effect is predominantly a lowering of the blood pressure in… Expand