guanoxan
National Institutes of Health
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The alpha-2 adrenoceptor antagonist idazoxan has been shown to also recognize with high affinity nonadrenoceptor sites (I2…
A three-dimensional molecular template has been generated for substrates of human debrisoquine 4-hydroxylase cytochrome P450…
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P…
In the present study we have investigated the substrate specificity of the form of cytochrome P-450 catalyzing the 4…
SummaryUntil quite recently, pharmacogenetic polymorphisms in oxidative drug metabolism were considered rare. However during the…
Eight volunteers previously phenotyped for their ability to hydroxylate debrisoquine (four extensive metabolisers (EM), four poor…