Genetically Determined Variability in Acetylation and Oxidation

@article{Clark1985GeneticallyDV,
  title={Genetically Determined Variability in Acetylation and Oxidation},
  author={Dylan J. Clark},
  journal={Drugs},
  year={1985},
  volume={29},
  pages={342-375}
}
SummaryThe clinical significance of two separate genetic polymorphisms which alter drug metabolism, acetylation and oxidation is discussed, and methods of phenotyping for both acetylator and polymorphic oxidation status are reviewed. Particular reference is made to the dapsone method, which provides a simple means of distinguishing fast and slow — and possibly intermediate — acetylators, and to the sparteine method which allows a clear separation of oxidation phenotypes.Although acetylation… CONTINUE READING

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