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A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps).
This paper describes the purification, sequence, and biological properties of a 38-amino acid residue peptide from the venom of Dendroaspis angusticeps which shared important sequence homologies withExpand
The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH.
This paper describes the properties of the amiloride-sensitive Na+/H+ antiporter in chick cardiac cells, compares them with those known in other cellular systems and analyzes the role of the Na+/H+Expand
Hypoxia Up-regulates Prolyl Hydroxylase Activity
The mechanism by which hypoxia induces gene transcription is now well established. Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in theExpand
The regulation of the intracellular pH in cells from vertebrates.
Eukaryotic cells control their intracellular pH using ion-transporting systems that are situated in the plasma membrane. This paper describes the different mechanisms that are involved and how theirExpand
The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation.
The human P2Y1 receptor heterologously expressed in Jurkat cells behaves as a specific adenosine 5'-diphosphate (ADP) receptor at which purified adenosine triphosphate (ATP) is an ineffectiveExpand
ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor.
Pharmacological properties of the human P2Y1 receptor transfected in Jurkat cells and of the endogenous receptor in rat brain capillary endothelial cells were analyzed under conditions in which theExpand
Characterization and Channel Coupling of the P2Y12Nucleotide Receptor of Brain Capillary Endothelial Cells*
Rat brain capillary endothelial (B10) cells express an unidentified nucleotide receptor linked to adenylyl cyclase inhibition. We show that this receptor in B10 cells is identical in sequence to theExpand
Analysis of the hypoxia-sensing pathway in Drosophila melanogaster.
The mechanism by which hypoxia induces gene transcription involves the inhibition of HIF-1alpha (hypoxia-inducible factor-1 alpha subunit) PHD (prolyl hydroxylase) activity, which prevents the VHLExpand
[Intracellular pH and its regulation].
  • C. Frelin
  • Biology, Medicine
  • Biochimie
  • 1 May 1984
Ciguatoxin is a novel type of Na+ channel toxin.
Purified ciguatoxin at 0.1 to 10 ng/ml inhibits the net accumulation of neurotransmitters (gamma-aminobutyric acid and dopamine) by brain synaptosomes. This action is due to a stimulation ofExpand