growth-differentiation factor 8

Known as: Myostatin, Myostatin [Chemical/Ingredient], Growth Differentiation Factor 8 
A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in… (More)
National Institutes of Health

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12 relations

Narrower (3)

GDF8 protein, humanGdf8 protein, ratmstn protein, zebrafish
In BloodProcess of secretionagonistsantagonists & inhibitors
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Broader (1)

Transforming Growth Factors

Papers overview

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Highly Cited
2009
Highly Cited
2009
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin… (More)
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Highly Cited
2008
Highly Cited
2008
Myostatin propeptide gene delivery by adeno-associated virus serotype 8 vectors enhances muscle growth and ameliorates dystrophic phenotypes in mdx mice.
Myostatin has been extensively documented as a negative regulator of muscle growth. Myostatin inhibition is therefore considered… (More)
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Highly Cited
2007
Highly Cited
2007
Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis.
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be… (More)
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Highly Cited
2003
Highly Cited
2003
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis.
Myostatin, a transforming growth factor beta (TGF-beta) family member, is a potent negative regulator of skeletal muscle growth… (More)
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Highly Cited
2003
Highly Cited
2003
Mechanisms involved in the inhibition of myoblast proliferation and differentiation by myostatin.
Muscle growth results from a set of complex processes including myogenic transcription factor's expression and activity, cell… (More)
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Highly Cited
2002
Highly Cited
2002
Myostatin inhibits myoblast differentiation by down-regulating MyoD expression.
Myostatin, a negative regulator of myogenesis, is shown to function by controlling the proliferation of myoblasts. In this study… (More)
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Highly Cited
2002
Highly Cited
2002
Loss of myostatin attenuates severity of muscular dystrophy in mdx mice.
Myostatin, a transforming growth factor-beta family member, is a negative regulator of skeletal muscle growth. To explore the… (More)
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Highly Cited
2002
Highly Cited
2002
Myostatin is an inhibitor of myogenic differentiation.
Myostatin (MSTN), a transforming growth factor (TGF)-beta superfamily member, has been shown to negatively regulate muscle growth… (More)
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Highly Cited
2001
Highly Cited
2001
Regulation of myostatin activity and muscle growth.
Myostatin is a transforming growth factor-beta family member that acts as a negative regulator of skeletal muscle mass. To… (More)
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Highly Cited
2000
Highly Cited
2000
Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation.
Myostatin, a member of the transforming growth factor-beta (TGF-beta) superfamily, has been shown to be a negative regulator of… (More)
Is this relevant?