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Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
TLDR
Results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth, which is significantly larger than wild-type animals and show a large and widespread increase in skeletal muscle mass.
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.
TLDR
It is shown that a dominant-negative TEAD molecule does not perturb normal liver growth but potently suppresses hepatomegaly/tumorigenesis resulting from YAP overexpression or Neurofibromin 2 (NF2)/Merlin inactivation.
Regulation of muscle mass by myostatin.
  • Se-Jin Lee
  • Biology, Medicine
    Annual review of cell and developmental biology
  • 8 October 2004
TLDR
The existence of circulating tissue-specific growth inhibitors of this type was hypothesized over 40 years ago to explain how sizes of individual tissues are controlled and skeletal muscle appears to be the first example of a tissue whose size is controlled by this type of regulatory mechanism.
Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11
TLDR
It is suggested that Gdf11 is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis.
Induction of Cachexia in Mice by Systemically Administered Myostatin
TLDR
It is shown that myostatin circulates in the blood of adult mice in a latent form that can be activated by acid treatment, and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired.
Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily
TLDR
The isolation of three new members of the transforming growth factor-β (TGF-β) superfamily5 (growth/differentiation factors (GDF) 5, 6 and 7) are reported and it is shown by mapping, expression patterns and sequencing that mutations in Gdf5 are responsible for skeletal alterations in bp mice.
Regulation of left-right patterning in mice by growth/differentiation factor-1
TLDR
It is shown that at early stages of mouse development, Gdf1 is expressed initially throughout the embryo proper and then most prominently in the primitive node, ventral neural tube, and intermediate and lateral plate mesoderm.
Regulation of muscle growth by multiple ligands signaling through activin type II receptors.
TLDR
A potent myostatin inhibitor, a soluble form of the activin type IIB receptor (ACVR2B), is described, which can cause dramatic increases in muscle mass when injected into wild-type mice.
Suppression of body fat accumulation in myostatin-deficient mice.
TLDR
It is shown that Mstn-null mice have a significant reduction in fat accumulation with increasing age compared with wild-type littermates, even in the setting of normal food intake, normal body temperature, and a slightly decreased resting metabolic rate.
Quadrupling Muscle Mass in Mice by Targeting TGF-ß Signaling Pathways
  • Se-Jin Lee
  • Biology, Medicine
    PloS one
  • 29 August 2007
TLDR
The capacity for increasing muscle growth by manipulating TGF-ß signaling pathways is much more extensive than previously appreciated and suggest that muscle mass may be controlled at least in part by a systemic mode of action of myostatin.
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