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A moment estimator of, the coancestry coefficient for alleles within a population, was described by Weir & Cockerham in 1984 and is still widely cited, by relating functions of theta values to times of population divergence under a pure drift model.
Linkage disequilibrium in finite populations
A theoretical investigation has been made of the influence of population size and recombination fraction on linkage disequilibrium between a pair of loci and it was found that the mean value ofr2 was determined almost entirely byN c and time, measured proportional toN.
Estimation of effective population size from data on linkage disequilibrium
- W. G. Hill
- 1 December 1981
A method is proposed for estimating effective population size from data on linkage disequilibrium among neutral genes at several polymorphic loci or restriction sites, but for very tightly linked genes estimates of N are more dependent on long-term than on recent population history.
Heritability in the genomics era — concepts and misconceptions
This work has shown that despite continuous misunderstandings and controversies over its use and application, heritability remains key to the response to selection in evolutionary biology and agriculture, and to the prediction of disease risk in medicine.
The effect of linkage on limits to artificial selection.
It was shown that the selection process can be completely specified by Ni α, Ni βand Nc and the initial gene frequencies and linkage disequilibrium coefficient and it is easily possible to generalize from computer runs at only one population size.
Variances and covariances of squared linkage disequilibria in finite populations.
Genome partitioning of genetic variation for complex traits using common SNPs
The results provide further evidence that a substantial proportion of heritability is captured by common SNPs, that height, BMI and QTi are highly polygenic traits, and that the additive variation explained by a part of the genome is approximately proportional to the total length of DNA contained within genes therein.
Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits
It is concluded that interactions at thelevel of genes are not likely to generate much interaction at the level of variance, and that additive variance typically accounts for over half, and often close to 100%, of the total genetic variance.
ESTIMATING VARIANCE COMPONENTS FOR TEST DAY MILK RECORDS BY RESTRICTED MAXIMUM LIKELIHOOD WITH A RANDOM REGRESSION ANIMAL MODEL
Additive Genetic Variability and the Bayesian Alphabet
The use of all available molecular markers in statistical models for prediction of quantitative traits has led to what could be termed a genomic-assisted selection paradigm in animal and plant…