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geldanamycin

Known as: geldanomycin 
A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (6)

Antibiotics, AntineoplasticAntiviral AgentsBenzoquinonesCysteine Proteinase Inhibitors

Narrower (1)

Geldanamycin Analogue
NCIt Antineoplastic Agent Terminologytanespimycin

Papers overview

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Highly Cited
2011
Highly Cited
2011
How well can fragments explore accessed chemical space? A case study from heat shock protein 90.
Highly Cited
2004
Highly Cited
2004
Luminal flow induces eNOS activation and translocation in the rat thick ascending limb.
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) acts as an autacoid to inhibit NaCl absorption in the thick… 
Review
2003
Review
2003
The role of apoptosis-inducing receptors of the tumor necrosis factor family in thyroid cancer.
The tumor necrosis factor (TNF) family comprises several ligands, such as the prototype TNF-alpha, the Fas ligand (FasL) and TNF… 
Highly Cited
2002
Highly Cited
2002
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein…
Under low oxygen tension, cells increase the transcription of specific genes involved in angiogenesis, erythropoiesis, and… 
Highly Cited
2000
Highly Cited
2000
Role of heat shock protein 90 in bradykinin-stimulated endothelial nitric oxide release.
Highly Cited
1998
Highly Cited
1998
Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton.
We use here a chimera of the green fluorescent protein (GFP) and the glucocorticoid receptor (GR) to test the notion that the… 
Highly Cited
1997
Highly Cited
1997
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo
Mutation of the tumor suppressor gene p53 is the most common genetic abnormality detected in human cancers. Wild type p53 is a… 
Highly Cited
1995
Highly Cited
1995
Geldanamycin selectively destabilizes and conformationally alters mutated p53.
Mutated p53 proteins interfere in the function of wild type p53 and may also serve as a dominant oncogene. The vast majority of… 
Highly Cited
1993
Highly Cited
1993
Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth.
Oncostatin-M (OSM) is a potent mitogen for Kaposi's sarcoma (KS) cells. We studied signaling by the OSM receptor in three AIDS… 
Highly Cited
1993
Highly Cited
1993
Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10.
IL-6 is a multi-functional cytokine that utilizes 80-kDa ligand-binding and 130-kDa signal-transducing subunits to stimulate… 
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