geldanamycin

Known as: geldanomycin 
A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
17-Allylamino-demethoxy geldanamycin (17-AAG) inhibits the chaperone association of heat shock protein 90 (hsp90) with the heat… (More)
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Highly Cited
2004
Highly Cited
2004
ErbB2 is a transmembrane tyrosine kinase whose surface overexpression is linked to tumorigenesis and poor prognosis in breast… (More)
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Highly Cited
2002
Highly Cited
2002
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits. HIF-1 is… (More)
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Review
2002
Review
2002
Geldanamycin (GA), herbimycin A and radicicol bind heat-shock protein-90 (Hsp90) and destabilize its client proteins including v… (More)
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Highly Cited
1998
Highly Cited
1998
Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein… (More)
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Highly Cited
1997
Highly Cited
1997
The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone… (More)
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Highly Cited
1997
Highly Cited
1997
Many functions of the chaperone, heat shock protein 90 (hsp90), are inhibited by the drug geldanamycin that specifically binds… (More)
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Highly Cited
1997
Highly Cited
1997
Hsp90 molecular chaperones in eukaryotic cells play essential roles in the folding and activation of a range of client proteins… (More)
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Highly Cited
1995
Highly Cited
1995
The plasma pharmacokinetics of the antitumor antibiotic geldanamycin (GM; NSC 122750), a naturally occurring benzoquinoid… (More)
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Highly Cited
1970
Highly Cited
1970
A new crystalline antimicrobial compound, geldanamycin, has been discovered in the culture nitrates of Streptomyces hygroscopicus… (More)
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