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geldanamycin

Known as: geldanomycin 
A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic… Expand
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
The plasma pharmacokinetics of the antitumor antibiotic geldanamycin (GM; NSC 122750), a naturally occurring benzoquinoid… Expand
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Highly Cited
2004
Highly Cited
2004
ErbB2 is a transmembrane tyrosine kinase whose surface overexpression is linked to tumorigenesis and poor prognosis in breast… Expand
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Highly Cited
2002
Highly Cited
2002
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits. HIF-1 is… Expand
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Highly Cited
2001
Highly Cited
2001
Huntington's disease (HD) is a progressive neurodegenerative disorder with no effective treatment. Geldanamycin is a benzoquinone… Expand
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Highly Cited
1999
Highly Cited
1999
The cellular activity of several regulatory and signal transduction proteins, which depend on the Hsp90 molecular chaperone for… Expand
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Highly Cited
1998
Highly Cited
1998
The molecular chaperone Hsp90 plays an essential role in the folding and function of important cellular proteins including… Expand
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Highly Cited
1997
Highly Cited
1997
The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone… Expand
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Highly Cited
1997
Highly Cited
1997
Many functions of the chaperone, heat shock protein 90 (hsp90), are inhibited by the drug geldanamycin that specifically binds… Expand
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Highly Cited
1996
Highly Cited
1996
Treatment of SKBr3 human breast carcinoma cells with the benzoquinoid ansamycin, geldanamycin, rapidly depletes p185c-erbB-2… Expand
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Highly Cited
1970
Highly Cited
1970
A new crystalline antimicrobial compound, geldanamycin, has been discovered in the culture nitrates of Streptomyces hygroscopicus… Expand
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