Geldanamycin Analogue

Known as: AAG, Geldanamycin Analog 
An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1971-2017
0102019712017

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND CRISPR/Cas is a widespread adaptive immune system in prokaryotes. This system integrates short stretches of DNA… (More)
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Highly Cited
2006
Highly Cited
2006
We show that multiple myeloma (MM), the second most commonly diagnosed hematologic malignancy, is responsive to hsp90 inhibitors… (More)
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Highly Cited
2004
Highly Cited
2004
Mutagenesis of protein-encoding sequences occurs ubiquitously; it enables evolution, accumulates during aging, and is associated… (More)
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Highly Cited
2004
Highly Cited
2004
To describe the preclinical basis for further development of 17-dimethyl aminoethylamino-17-demethoxygeldanamycin hydrochloride… (More)
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2004
2004
The natural modification of specific nucleosides in many tRNAs is essential during decoding of mRNA by the ribosome. For example… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Sex steroids, particularly androgens, have been implicated in the pathogenesis of prostate cancer. Data from previous… (More)
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Highly Cited
1996
Highly Cited
1996
The p53 mutant, 143ala, was translated in vitro in either rabbit reticulocyte lysate (RRL) or wheat germ extract (WGE). In RRL… (More)
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Highly Cited
1996
Highly Cited
1996
A sparse sampling strategy (3 samples per patient, 521 patients) was implemented in 22 Phase 2 studies of docetaxel (Taxotere… (More)
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1993
1993
Clinical experience has indicated that the effects of RU 486 can be divided into dose-dependent and dose-independent effects… (More)
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Highly Cited
1989
Highly Cited
1989
In a previous report it was shown that mammalian ribosomes were capable of initiating translation at a non-AUG triplet when the… (More)
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