Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

  title={Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo},
  author={Luke Whitesell and Patrick D Sutphin and Wen G An and Theodor W. Schulte and Mikhail V. Blagosklonny and Leonard M. Neckers},
Mutation of the tumor suppressor gene p53 is the most common genetic abnormality detected in human cancers. Wild type p53 is a short-lived protein with very low basal intracellular levels. Most mutated forms of the protein, however, display markedly increased intracellular levels as an essential feature of their positive transforming activity. In this report, we have used selective inhibitors of the 20S proteasome to demonstrate that processing of p53 by ubiquitination and proteasome-mediated… CONTINUE READING


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