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We searched for specific inhibitors of the futalosine pathway, non-canonical pathway of menaquinone biosynthesis operating in… Expand The recently discovered futalosine-dependent menaquinone biosynthesis pathway employs radical chemistry for the naphthoquinol… Expand Menaquinone (MK) is an important component of the electron-transfer system in prokaryotes. One of its precursors, 1,4-dihydroxy-2… Expand The recently discovered futalosine pathway is a promising target for the development of new antibiotics. The enzymes involved in… Expand Background: Specific pathways and components for respiration in Chlamydia are poorly understood. Results: The C. trachomatis… Expand The radical S-adenosylmethionine enzyme MqnC catalyzes conversion of dehypoxanthine futalosine (DHFL) to the unique spiro… Expand In prokaryotes, menaquinone (MK) is involved in an electron-transfer pathway. Its biosynthesis was established in the 1970s and… Expand Menaquinone (vitamin K2) serves as an electron carrier in the electron transport chain required for respiration in many… Expand ABSTRACT We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone… Expand In prokaryotes, menaquinone is used for respiration. In Escherichia coli, menaquinone is biosynthesized from chorismate by seven… Expand