formestane

Known as: Formestano, 4-hydroxyandrostene-3,17-dione, 4-hydroxyandrostenedione 
A synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
0102019772017

Papers overview

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Highly Cited
2003
Highly Cited
2003
Aromatase inhibitors have recently been reported to be more effective than the antiestrogen tamoxifen (Tam) in treating breast… (More)
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Highly Cited
2000
Highly Cited
2000
There is increasing concern that certain chemicals in the environment can cause endocrine disruption in exposed humans and… (More)
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Highly Cited
1998
Highly Cited
1998
  • W Yue, J P Wang, C J Hamilton, L M Demers, R J Santen
  • Cancer research
  • 1998
The high concentrations of estradiol (E2) found in breast tumors of postmenopausal women could be the result of enhanced uptake… (More)
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Highly Cited
1994
Highly Cited
1994
  • W Yue, D Zhou, S Chen, A Brodie
  • Cancer research
  • 1994
MCF-7 cells transfected with human placental aromatase gene (MCF-7Ca cells) or cells transfected with plasmid vector only (MCF… (More)
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Highly Cited
1990
Highly Cited
1990
  • D J Zhou, D Pompon, S A Chen
  • Cancer research
  • 1990
A mammalian cell expression plasmid, pH beta-Aro, containing the human placenta aromatase complementary DNA was constructed. The… (More)
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1990
1990
Although testosterone (T) stimulates aggressive and reproductive behaviors in males of many vertebrate species, it is now known… (More)
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Highly Cited
1987
Highly Cited
1987
4-Hydroxyandrostenedione (4-OHA) is a potent inhibitor of estrogen production by aromatase and causes suppression of plasma… (More)
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Highly Cited
1986
Highly Cited
1986
4-Hydroxyandrostenedione (4-OHA), a potent new aromatase inhibitor, was given i.m. (500-1000 mg) to 58 patients with advanced… (More)
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Highly Cited
1984
Highly Cited
1984
4-hydroxyandrostenedione, a potent inhibitor of the aromatase (oestrogen synthetase) system, was given to 11 patients with… (More)
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Highly Cited
1977
Highly Cited
1977
4-Hydroxy-f-androstene-3,17-dione (4-OH-A) when tested at various concentrations was found to inhibit markedly the conversion of… (More)
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