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formestane

Known as: Formestano, 4-hydroxyandrostene-3,17-dione, 4-Hydroxyandrostenedione 
A synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

AndrostenedioneAntineoplastic AgentsAromatase Inhibitors

Narrower (1)

CGP 32349
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Postmenopausal Breast Cancer Patients and Intramuscular 4-Hydroxyandrostenedione in Dose-related Endocrine Effects and Pharmacokinetics of Oral Updated
4-Hydroxyandrostenedione (CGP32349; 4-OHA) is a clinically effec tive treatment for advanced postmenopausal breast cancer by both… 
1998
1998
Severe immune thrombocytopenia during formestane treatment.
Formestane is a new aromatase inhibitor used as second-line endocrine treatment for postmenopausal women with advanced breast… 
1990
1990
Lack of evidence for aromatase in human prostatic tissues: Effects of 4-hydroxyandrostenedione and other inhibitors on androgen metabolism: Editorial comment
1986
1986
Regulation of progesterone formation by human placental cells in culture.
In the present study, a culture system of human placental cells was established to examine the role of estrogen and androgen in… 
1986
1986
Studies on the possible existence of two 5 alpha-reductases in the rat prostate.
In the first group of experiments, the in vitro metabolism of labelled testosterone has been studied in the ventral prostate of… 
1984
1984
Synthesis and evaluation of 19-aza- and 19-aminoandrostenedione analogues as potential aromatase inhibitors.
Derivatives of 19- azaandrostenedione (10 beta-amino-4- estrene -3,17-dione, 2) and 19-amino-4-androstene-3,17-dione (3) were… 
1983
1983
1. Estrogen antagonists. Aromatase inhibitors, their pharmacology and application.
Aromatase inhibitors, 4-OHA, 4-acetoxy-A and ATD cause competitive inhibition and inactivation of aromatase in vitro. The latter… 
Review
1982
Review
1982
Overview of recent development of aromatase inhibitors.
Since the first publication in 1973 concerning aromatase inhibitors, several effective compounds have been reported by a number… 
1982
1982
Effect of aromatase inhibitor on oestrogen production in rabbit blastocysts.
Summary. Oestradiol-17\g=b\was produced by cultures of 5- and 6-day rabbit blastocysts containing 0\m=.\5\p=n-\1\g=m\M-[3H… 
1978
1978
Reactions of 4beta,5-epoxy-5beta-androstan-3-ones with hydrogen fluoride in pyridine.
4beta,5-Epoxy-5beta-androstane-3,17-dione (1a), 17beta-hydroxy-4beta,5-epoxy-5beta-androstan-3-one (1b) and 17beta-acetoxy-4beta… 
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